Developments in Stem Cell-Derived Islets for Diabetes Cell Replacement Therapy


This Friday, May 20, we will welcome Jeffrey Millman, Associate Professor of Medicine and Biomedical Engineering at Washington University School of Medicine. His current research is focused on synergizing both biomedical engineering and cell biology approaches to use stem cells for the study and treatment of diabetes.

The contemporary drug discovery process faces two major challenges:
1) a lack of predictive models that accurately mimic the in vivo response of native tissues during drug screening, and
2) limitations in high throughput identification and isolation of target compounds with pharmaceutical activity.

The technological advancement of engineering fields such as biofabrication and microfabrication can help to overcome these obstacles. In this talk, we will discuss the use of biofabrication for engineering in vitro tissue constructs for drug screening: this talk will focus on the selection of biomaterials as well as suitable deposition methods. We will also discuss the use of microfabrication for developing in situ bacterial cultivation techniques to overcome “the great plate count anomaly” and aid in the discovery of novel bioactive compounds.
 


FRIDAY, MAY 20, 2022 – 12 P.M. TO 1 P.M. 

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Jeffrey Millman is currently an Associate Professor of Medicine and Biomedical Engineering at Washington University School of Medicine. He received his PhD from MIT and completed his postdoctoral training in the laboratory of Dr. Douglas Melton at Harvard University. His current research is focused on synergizing both biomedical engineering and cell biology approaches to use stem cells for the study and treatment of diabetes. He is developing new approaches for the differentiation of insulin-producing islets from stem cells and improving their utility for cell replacement therapy and in vitro disease models. His innovations have been licensed to several biotechnology and startup companies in the diabetes space and resulted in one ongoing clinical trial. His laboratory is supported by the NIH NIDDK and JDRF, and his scholarship has been recently recognized by awards from the JDRF, American Institute of Chemical Engineering, and the Biomedical Engineering Society.

Guess of Gareth Lim
Cardiometabolic Research Theme


We look forward to seeing you connected in large numbers!


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