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Resilience-to-Frailty in Older Adults: A Window on Lifelong Health

Conférencière : Karen Bandeen-Roche, Ph.D. Professeure au Département de biostatistiques de l'Université de John Hopkins (Baltimore, Maryland) Co-directrice du centre pour l'indépendance des personnes âgées de l'Université de John Hopkins (Baltimore, Maryland) Sujet de la conférence : The physical resilience concept aims to promote positive outcomes following stressors to older adults. To achieve this aim, we must determine physiologic mechanisms underlying either capacity to respond resiliently, or, when critically dysregulated, frailty. The Johns Hopkins Older Americans Independence Center studies the resilience-to-frailty spectrum: First, its major concepts and research contributions are outlined. Then, we describe the recent Study of Physical Resilience and Aging, which implemented stimulus-response tests to characterize physiological fitness in older adults scheduled for major stressors (e.g., total knee replacement -TKR). We report work to develop physiologic resilience measures from these stimulus-response data and study their associations with functional resilience following TKR. Our study lays groundwork to better foster older adults’ resilience to stressors and, ultimately, overall health. Conférence enregistrée le 20 mai 2025.