Our highly specialized team has the expertise to produce radiopharmaceuticals for Positron Emission Tomography (PET) imaging studies involving diagnosis, follow-up and better understanding of diseases. For instance, the fluorine-18 (18F) can be incorporated into a fatty acid derivative, 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid ([18F]FTHA), which accumulates in tissues with abnormal fatty acid metabolism, and thus can be useful in identifying disturbances in fat metabolism in specific tissues/ organs.
Our team works in the implementation of existing radiotracers for clinical research. We are also conducting several innovative research projects developing new promising radiolabeled molecules to improve the detection, to monitor treatment efficacy and to better understand the progression of diseases such as cancer, diabetes, neurodegenerative and cardiovascular diseases. This non-invasive imaging technology allows a fast and efficient translation of important findings from the fundamental research to the clinic via preclinical research.
The production of these radiotracers is performed in GMP environment. More importantly, automated modules in shielded hot cells, including two cells equipped with telemanipulator robotic arms enable the synthesis and manipulation of these radiotracers without any exposure of the Radiochemistry and Cyclotron personnel to radioactivity. Moreover, the distribution of these radiotracers to the injection room, either at the CRCHUM animal facility or at the new CHUM nuclear medicine facility for injections to patients, is greatly facilitated by a pneumatic system, which quickly delivers the radiotracers in less than a minute.
Our services are available to researchers from universities, hospitals and for projects in partnership with the industry.
EQUIPMENTS AND SERVICES
The CRCHUM Radiochemistry and Cyclotron core-facility has an IBA cyclotron Cyclone® 18/9 MeV. This particle accelerator is used to produce PET radioisotopes, including Carbon-11, Fluorine-18 (via a small or a large target) and the Nitrogen-13.
We have the necessary expertise and the equipments to manufacture existing F-18 and C-11 radiolabeled radiopharmaceuticals, as well as a qualified team in research and development of new PET radiotracers.
Our laboratory also offers several quality control tests, including endotoxin evaluation, residual solvent quantification by using gas chromatography (GC) and the chemical purity assessment of samples by using high pressure liquid chromatography (HPLC).
CYCLOTRON 18 MEV
- 2 GMP laboratories
- COMECER® shielded hot cells.
- Chemistry laboratory
- Quality control laboratory
- IBA Synthera® Chemistry (F-18)
- IBA Synthera® HPLC
- 2 Synthra® RNplus Research (F-18 modules)
- Synthra® MeIplus (C-11 module)
- Agilent® gas chromatography (GC) with liquid or headspace auto-injector
- Agilent® high pressure liquid chromatography (HPLC) with auto-injector
- 2 HPLC Waters systems
- HPLC Shimadzu system
- Endosafe PTS Endotoxin system
Our cyclotron could also generate (15O2; 124I et 64Cu).
For any service or submission request, please fill out the electronic form or contact the Technical Supervisor.
Scientific Manager: Jean DaSilva, Ph.D.
Supervisor: José-Mathieu Simard, B.Sc.
Specialists: Alejandro Hernandez, M.Sc., Charles Olivier Normandeau, M.Sc., Baptiste Fezas, M.Sc.
Radiotracers development specialist: Luis Michel Alonso Martinez, Ph.D.
Cyclotron engineer: Nabil Naim, Ing.
514 890-8000, ext. 30589
For the reason of the unique features of each project in radiochemistry, a quotation for the entire project can be provided upon request.
INFORMATION REQUEST - RADIATION PROTECTION
For any radiation protection information request or inquiry, please contact the radiation safety officer.
Radiation safety officer : Frédérique Piché, M.Sc.
514-890-8000, ext. 25854