Parkinson et parkinsonismes

Médicaments

• Anti-osteoporosis medications in persons with and without Parkinson disease in Finland
  Le 29 octobre 2026

  Arch Osteoporos. 2026 Oct 5;21(1):143. doi: 10.1007/s11657-026-01780-z. ABSTRACT Contrary to reports on under-treatment in persons with Parkinson's disease, our study found similar anti-osteoporosis…

• Dopaminergic state modulates shame and contextual emotional responses in Parkinson's disease
  Le 29 octobre 2026

  J Parkinsons Dis . 2026 Oct 9:1877718X261491589. doi: 10.1177/1877718X261491589. Online ahead of print. ABSTRACT BackgroundShame is frequent in Parkinson's disease (PD) and negatively affects quality…

• The site of absorption matters: Small bowel dysmotility and levodopa pharmacokinetics in Parkinson's disease
  Le 29 octobre 2026

  J Parkinsons Dis . 2026 Sep 29:1877718X261490414. doi: 10.1177/1877718X261490414. Online ahead of print. ABSTRACT Plain language summary Looking Past the Stomach to the Small Intestine to Explain…

• Effects of butylphthalide plus donepezil on symptoms, cognitive function, and oxidative stress in patients with cognitive impairment in Parkinson's disease
  Le 29 octobre 2026

  Am J Transl Res. 2026 Sep 15;18(9):7841-7850. doi: 10.62347/FTLS7614. eCollection 2026. ABSTRACT OBJECTIVE: To investigate the effects of butylphthalide combined with donepezil on clinical symptoms,…

• Ekbom Spectrum Psychosis Associated with 24-hour Continuous Subcutaneous Foslevodopa/Foscarbidopa Infusion in Parkinson's Disease
  Le 29 octobre 2026

  Clin Psychopharmacol Neurosci. 2026 Nov 30;24(4):885-889. doi: 10.9758/cpn.26.1449. Epub 2026 Oct 4. ABSTRACT Continuous subcutaneous foslevodopa/foscarbidopa infusion (CSFLI) is an emerging…

Études cliniques phase 3 et phase 4

• Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease: The NOPARK Randomized Clinical Trial
  Le 29 octobre 2026

  JAMA. 2026 Oct 8. doi: 10.1001/jama.2026.18828. Online ahead of print. ABSTRACT IMPORTANCE: Nicotinamide riboside, a nicotinamide adenine dinucleotide precursor, has been proposed as a potential…

• Target engagement and efficacy in disease-modifying trials of synuclein-related disorders
  Le 29 octobre 2026

  Brain. 2026 Oct 12:awag353. doi: 10.1093/brain/awag353. Online ahead of print. ABSTRACT Disease-modifying trials in Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy…

• Automated eye-tracking for Parkinson's disease diagnosis: a proof-of-concept cascade classifier study
  Le 29 octobre 2026

  Clin Park Relat Disord. 2026 Oct 2;15:100509. doi: 10.1016/j.prdoa.2026.100509. eCollection 2026. ABSTRACT BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder of…

• Mechanistic Evaluation of Psilocybin in Neurodegenerative Disorders: Relevance of 5-HT2A Receptors and Downstream Pathways
  Le 29 octobre 2026

  CNS Neurol Disord Drug Targets. 2026 Oct 14. doi: 10.2174/0118715273491538261009064612. Online ahead of print. ABSTRACT More than fifty million individuals worldwide are experiencing…

• Considerations for therapeutic targets for clinical trials in biomarker-characterized prodromal Parkinson's disease populations
  Le 29 octobre 2026

  J Parkinsons Dis . 2026 Oct 8:1877718X261493297. doi: 10.1177/1877718X261493297. Online ahead of print. ABSTRACT Parkinson's disease (PD) is a growing public health problem and biologically targeted…

• New guidance and public search portal for clinical trials approved in Canada: Notice
  Le 28 septembre 2026

  Our file number: 26-104462-113 July 29, 2026 On this page What we did About the guidance document About the search portal Contact us What we did Health Canada has a new guidance on registering…

Chirurgie

• Predictive factors associated with interval changes in STN-DBS lead-tip position between immediate and delayed postoperative CT
  Le 30 octobre 2026

  Neurosurg Rev. 2026 Oct 17;49(1):614. doi: 10.1007/s10143-026-04530-4. ABSTRACT BACKGROUND: Brain shift during deep brain stimulation (DBS) surgery may contribute to changes in lead position…

• Pre-operative neural substrates of deep brain stimulation outcomes: A systematic review and cross-disorder network synthesis
  Le 30 octobre 2026

  Neurosci Biobehav Rev. 2026 Dec;191:106977. doi: 10.1016/j.neubiorev.2026.106977. Epub 2026 Sep 17. ABSTRACT BACKGROUND: Deep brain stimulation (DBS) is an established therapy for movement and…

• Preoperative neuropsychological prognostic factors for deep brain stimulation in Parkinson's disease
  Le 30 octobre 2026

  Clin Neurol Neurosurg. 2026 Oct 9;272:109669. doi: 10.1016/j.clineuro.2026.109669. Online ahead of print. ABSTRACT BACKGROUND: Preoperative neuropsychological evaluation is standard in deep brain…

• Moving Beyond the Hyperkinetic Hypothesis for Weight Gain After Deep Brain Stimulation in Parkinson Disease
  Le 28 septembre 2026

  Neuromodulation. 2026 Aug 4:S1094-7159(26)01321-8. doi: 10.1016/j.neurom.2026.07.651. Online ahead of print. ABSTRACT OBJECTIVES: Weight loss is a common manifestation of Parkinson disease (PD) and…

• Pre-operative neural substrates of deep brain stimulation outcomes: A systematic review and cross-disorder network synthesis
  Le 28 septembre 2026

  Neurosci Biobehav Rev. 2026 Sep 17;191:106977. doi: 10.1016/j.neubiorev.2026.106977. Online ahead of print. ABSTRACT BACKGROUND: Deep brain stimulation (DBS) is an established therapy for movement…

Approches multidisciplinaires

• Teamwork in Parkinson's care: Building multidisciplinary models worldwide
  Le 29 octobre 2026

  J Parkinsons Dis . 2026 Oct 22:1877718X261499242. doi: 10.1177/1877718X261499242. Online ahead of print. ABSTRACT Parkinson's disease (PD) is a complex, progressive neurodegenerative disorder…

• Clinical efficacy and safety of electroacupuncture at the motor area for Parkinson's disease with musculoskeletal pain: a randomized controlled trial
  Le 28 septembre 2026

  Zhongguo Zhen Jiu. 2026 Sep 12;46(9):1415-1420. doi: 10.13703/j.0255-2930.20250604-k0002. Epub 2026 Jul 6. ABSTRACT OBJECTIVE: To observe the clinical efficacy and safety of electroacupuncture (EA)…

• Stress and Parkinson's disease: from dysfunctional detection to impaired handling: a narrative review
  Le 28 septembre 2026

  J Neural Transm (Vienna). 2026 Sep 24. doi: 10.1007/s00702-026-03267-0. Online ahead of print. ABSTRACT Stress can precipitate Parkinson's disease (PD), and conversely, PD imposes substantial stress…

• Neurogrit Gold Alleviates Motor, Behavioural, and oxidative stress deficits in the MPTP-induced Drosophila melanogaster model of Parkinson's disease
  Le 28 septembre 2026

  Brain Res. 2026 Sep 7:150542. doi: 10.1016/j.brainres.2026.150542. Online ahead of print. ABSTRACT Parkinson's disease is characterized by degeneration of dopaminergic neurons in the midbrain,…

• Dual-Task Exercises for Dynamic Balance, Motor Function, Functional Mobility, and Dual-Tasking in Individuals With Parkinson's Disease: A Meta-Analysis With Meta-Regression
  Le 28 septembre 2026

  Ann Rehabil Med. 2026 Aug;50(4):244-264. doi: 10.5535/arm.260060. Epub 2026 Aug 28. ABSTRACT To evaluate the (1) effectiveness of dual-task (DT) exercise in improving dynamic balance, motor function,…

Thérapies alternatives

• Stem cell therapy improves motor function in Parkinson’s trial, data show
  Le 29 octobre 2026

  XS411, Xellsmart ’s experimental stem cell therapy, was generally well tolerated and associated with improved motor function in people with Parkinson’s disease , according to new Phase 1 clinical…

• MUSIC-PD: A Delphi-Derived, Culturally Adaptable Music Therapy Protocol for Parkinson's Disease Rehabilitation
  Le 29 octobre 2026

  Mov Disord Clin Pract. 2026 Oct 27. doi: 10.1002/mdc3.70860. Online ahead of print. ABSTRACT BACKGROUND: Music-based interventions have shown promise in Parkinson's disease (PD) rehabilitation…

• Impact of group singing on communication and quality of life in individuals with Parkinson's disease: A qualitative study
  Le 29 octobre 2026

  Int J Speech Lang Pathol. 2026 Oct 4:1-14. doi: 10.1080/17549507.2026.2735366. Online ahead of print. ABSTRACT PURPOSE: Parkinson's disease is a progressive neurological condition that negatively…

• Effectiveness of mindfulness meditation on balance, cognitive functions, quality of life, and falls prevention in Parkinson's disease: A systematic review
  Le 28 septembre 2026

  Neuropsychol Rehabil. 2026 Sep 7:1-34. doi: 10.1080/09602011.2026.2725697. Online ahead of print. ABSTRACT Scientific interest in mindfulness meditation as complementary therapy for Parkinson's…

• Effects of eccentric upper limbs exercises, added with virtual reality, on tremor and upper limbs function in people with Parkinson's disease: A randomized clinical trial
  Le 28 septembre 2026

  J Hand Ther. 2026 Sep 22:S0894-1130(26)00062-1. doi: 10.1016/j.jht.2026.06.002. Online ahead of print. ABSTRACT BACKGROUND: Parkinson's disease is a progressive neurodegenerative disorder. Eccentric…

• Measuring what matters: Evaluating quality of life instruments through the eyes of people with Parkinson's disease
  Le 29 octobre 2026

  J Parkinsons Dis . 2026 Oct 8:1877718X261480905. doi: 10.1177/1877718X261480905. Online ahead of print. ABSTRACT BackgroundMany instruments are used to assess quality of life in people living with…

• Dysarthria and idiopathic Parkinson's disease: a current overview of the relationship between speech impairment and quality of life
  Le 29 octobre 2026

  Arq Neuropsiquiatr. 2026 Oct;84(10):1-6. doi: 10.1055/s-0046-1829126. Epub 2026 Oct 23. ABSTRACT Idiopathic Parkinson's disease (IPD) is a chronic and progressive neurodegenerative disorder…

• Caregiver Burden and Its Determinants After Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease: A Cross-Sectional Long-Term Follow-Up Study
  Le 29 octobre 2026

  Mov Disord Clin Pract. 2026 Oct 12. doi: 10.1002/mdc3.70851. Online ahead of print. ABSTRACT BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder, leading to increasing…

• Noninvasive brain stimulation for motor function and quality of life in Parkinson's disease: a systematic review and network meta-analysis
  Le 29 octobre 2026

  J Clin Neurosci. 2026 Oct 15;155:112347. doi: 10.1016/j.jocn.2026.112347. Online ahead of print. ABSTRACT BACKGROUND: Parkinson's disease (PD) seriously affects the motor function and quality of life…

• The Impact of Neuropalliative Care on Caregivers of Individuals with Motor Neuron Disorders or Atypical Parkinsonism
  Le 29 octobre 2026

  J Hosp Palliat Nurs. 2026 Oct 12. doi: 10.1097/NJH.0000000000001263. Online ahead of print. ABSTRACT Neurodegenerative disorders, including motor neuron disease (MND) and atypical parkinsonism (AP),…

• 'To Hear and Be Heard': The Co-Design of a Website to Support Communication Challenges Experienced by People With Parkinson's and Their Families and Friends
  Le 29 octobre 2026

  Int J Lang Commun Disord. 2026 Nov-Dec;61(6):e70353. doi: 10.1111/1460-6984.70353. ABSTRACT BACKGROUND: There is growing recognition that health research should reflect the needs and perspectives of…

• Technology to remotely capture key elements of swallowing and speech: State of the science in Parkinson's disease
  Le 29 octobre 2026

  J Parkinsons Dis . 2026 Oct 9:1877718X261470565. doi: 10.1177/1877718X261470565. Online ahead of print. ABSTRACT Swallowing and speech impairments are common in Parkinson's disease (PD) and can…

• Meaningful digital mobility outcomes for people with Parkinson's disease: Insights grounded in diverse lived experience
  Le 29 octobre 2026

  J Parkinsons Dis . 2026 Oct 9:1877718X261494917. doi: 10.1177/1877718X261494917. Online ahead of print. ABSTRACT BackgroundDigital mobility outcomes (DMOs) have been cited as potential clinical…

• Sensor-integrated AI-assisted gait training in dementia and Parkinson's disease: A single-session pre-post study
  Le 29 octobre 2026

  Technol Health Care. 2026 Oct 15:9287329261498488. doi: 10.1177/09287329261498488. Online ahead of print. ABSTRACT BackgroundGait impairment in dementia and Parkinson's disease (PD) contributes to…

• Home-based virtual reality telerehabilitation for people with Parkinson's disease: a scoping review of delivery, supervision and implementation
  Le 29 octobre 2026

  BMJ Open. 2026 Sep 29;16(9):e119628. doi: 10.1136/bmjopen-2026-119628. ABSTRACT OBJECTIVE: To map the delivery models, supervision approaches and implementation characteristics of home-based virtual…

Québec

• CRiNQUÉ, ça sort d’où ?
  Le 29 octobre 2026

  CRiNQUÉ, ça sort d’où ? On voulait un nom qui a du punch. Un nom qui parle de l’énergie qu’on se donne quand ça nous tente un peu moins de bouger... mais qu’on y va pareil ! 💪 C’est comme ça que…

• DÉFI ALLEZ AU BOUT : 8 semaines pour bouger, progresser et se dépasser !
  Le 29 octobre 2026

  DÉFI ALLEZ AU BOUT : 8 semaines pour bouger, progresser et se dépasser ! 🌟 https://crinque.thinkific.com/ Parkinson Québec et ses partenaires régionaux vous invite à découvrir CRiNQUÉ, une plateforme…

• Pas besoin de sortir ni d’avoir de l’équipement spécial pour prendre soin de son corps
  Le 29 octobre 2026

  Pas besoin de sortir ni d’avoir de l’équipement spécial pour prendre soin de son corps. Avec Crinqué, la plateforme en ligne d’activités physiques adaptées de Parkinson Québec, l’activité physique se…

• Certains jours, l’énergie est au rendez-vous
  Le 29 octobre 2026

  Certains jours, l’énergie est au rendez-vous. D’autres jours, les symptômes, la fatigue ou simplement la motivation rendent les choses plus difficiles. Et c’est normal. Avec CRiNQUÉ, ce qui fait la…

• Vivre avec le Parkinson, ce n’est pas seulement ce qui se passe dans le bureau du médecin
  Le 29 octobre 2026

  Vivre avec le Parkinson, ce n’est pas seulement ce qui se passe dans le bureau du médecin. C’est aussi tout ce qui se passe entre les rendez-vous. Le jeudi 29 octobre, venez échanger avec Line…

• Photos from Parkinson Québec's post
  Le 29 octobre 2026

  🔬 Qu’est-ce que la recherche participative ? Et si les personnes vivant avec la maladie de Parkinson et leurs proches jouaient un rôle actif dans la recherche ? La recherche en santé évolue afin d…

• En 2024, Pierre perdait l’équilibre, avait de la difficulté à avaler et sa voix s’éteignait peu à peu
  Le 29 octobre 2026

  En 2024, Pierre perdait l’équilibre, avait de la difficulté à avaler et sa voix s’éteignait peu à peu. Sylvia, elle, est devenue proche aidante. Elle a appris la patience, et ensemble ils ont trouvé…

• Transpirer de façon excessive, c’est un symptôme méconnu de la maladie de Parkinson
  Le 29 octobre 2026

  Transpirer de façon excessive, c’est un symptôme méconnu de la maladie de Parkinson. Il peut pourtant avoir un vrai impact au quotidien. 💧 Pour mieux le comprendre, le laboratoire du Pr Christian…

Canada

• Quand la maladie de Parkinson fait mal : les causes de la douleur et de la dystonie, et ce qui peut aider
  Le 29 octobre 2026

  Points clés La douleur liée à la maladie de Parkinson est fréquente et peut apparaître des années avant des symptômes plus connus comme les tremblements ou la raideur. La plupart des personnes vivant…

• Hard Work & Laughter: Our “Person-Centered Approach” in Action
  Le 29 octobre 2026

  By a BC Brain Wellness Program Volunteer The BC Brain Wellness Program takes a “person-centered approach” to its work. The description comes to life when you spend time with one of the Program’s in…

• Lancez votre assurance : Parkinson Canada s’associe à Spotify
  Le 28 septembre 2026

  Un rythme bien à soi Chacun bouge à son propre rythme. Cette idée est au cœur de Trouvez votre assurance, la campagne continue de Parkinson Canada visant à redéfinir la façon dont les personnes…

États-Unis

• How can Parkinson’s affect communication and connection?
  Le 29 octobre 2026

  How can Parkinson’s affect communication and connection? Hear from MJFF's Dr. Rachel Dolhun, a movement disorders neurologist and principal medical advisor. She speaks with speech-language…

• First patient dosed in clinical trial of oral treatment for Parkinson’s
  Le 29 octobre 2026

  The first patient has been dosed in Mission Therapeutics ’ Phase 1b clinical trial of MTX325, an oral treatment for Parkinson’s disease . With several locations open in the U.K., France, Germany, and…

• Having good and bad days can be confusing with Parkinson’s disease
  Le 29 octobre 2026

  Parkinson’s disease can cause a wide variety of symptoms, from losing your sense of smell to having terrible gait issues that result in multiple falls a day. And they don’t happen in any particular…

• Mayo Clinic tests low-dose radiation to slow Parkinson’s progression
  Le 29 octobre 2026

  Researchers at Mayo Clinic are testing whether low-dose radiation therapy can slow the progression of Parkinson’s disease by reducing inflammation in affected areas of the brain. According to Mayo…

• Parkinson’s cognitive issues hit 1 in 3, highlighting screening need
  Le 29 octobre 2026

  Cognitive issues affect about one in three people with Parkinson’s disease , a meta-analysis found, highlighting the importance of early screening and long-term research into the causes and early…

• Parkinson’s can bring changes in mood and motivation, sometimes years before motor symptoms appear
  Le 29 octobre 2026

  Parkinson’s can bring changes in mood and motivation, sometimes years before motor symptoms appear. Many people experience depression, anxiety or apathy as part of their Parkinson’s journey, but it…

• Fatigue in Parkinson’s Disease and How to Manage It
  Le 29 octobre 2026

  The motor symptoms of Parkinson’s disease (PD) are often the most recognized and treated, but the non-motor symptoms can have just as significant an impact on everyday life. One of the most common…

• Does cannabis help Parkinson’s symptoms?
  Le 29 octobre 2026

  Does cannabis help Parkinson’s symptoms? This time, we’re looking at the bigger picture — what studies have shown so far, what the latest trials add, and where the research is headed next. Read some…

• Parkinson’s affects women differently from men, study shows
  Le 29 octobre 2026

  Women with Parkinson’s disease experience more severe motor complications and depression, while men are more likely to have cognitive difficulties, reduced sense of smell, and sleep disturbances,…

• Oral therapy shows encouraging results for early Parkinson’s disease
  Le 29 octobre 2026

  In a small proof-of-concept clinical trial, Biovie ’s experimental oral therapy bezisterim was associated with significantly greater improvements in motor and nonmotor symptom scores than a placebo…

International

• Parkinson’s disease research and drug development tops Michael J. Fox Foundation’s conference in New York
  Le 29 octobre 2026

  Therapies to slow the progression of Parkinson’s and improve the symptoms through patient-centred care initiatives topped the agenda at the Michael J. Fox Foundation’s annual Parkinson’s Disease…

• RALENTIR, STOPPER, OU FAIRE RECULER PARKINSON : le pari des essais plateformes pour accélérer la recherche
  Le 29 octobre 2026

  RALENTIR, STOPPER, OU FAIRE RECULER PARKINSON : le pari des essais plateformes pour accélérer la recherche Le 16 Novembre 2026 à l’Institut du Cerveau à Paris Le 16 Novembre 2026 à l’Institut du…