Douleur chronique

Author Names: Oliveira, D.,Rocha, N.P.,Silva, A.G. Database Source: Embase Daily Updates Journal Title: PLOS One Article Title: Feasibility, acceptability and usability of InControl web-platform intervention for older adults with chronic musculoskeletal pain: A mixed-methods pilot study protocol Year: 2026 Issue: 10 October Volume: 21 Abstract: Background: Chronic musculoskeletal pain is highly prevalent among older adults and is associated with disability, reduced physical activity, and decreased quality of life. Digital health interventions can improve access to care and support pain self-management. InControl is a user-centered web-based platform that combines exercise and pain science education. The aim of this pilot study is to assess the usability and acceptability of the InControl platform and the feasibility of the research methods. This will help inform methodological improvements in the design of a future randomized controlled trial. <br/>Method(s): A randomized, parallel-group, mixed-methods pilot study will be conducted with two groups: usual care group and the InControl intervention. Thirty-four participants aged 60 years or older with chronic musculoskeletal pain will be recruited at the Local Health Unit of Aveiro Region. The InControl intervention will last 8 weeks and will combine in-person sessions with remote interventions. Feasibility will be assessed using indicators of recruitment, retention, adherence, refusal, and dropout rates. Usability will be measured using the System Usability Scale, while acceptability and appropriateness will be assessed through a questionnaire and semi-structured interviews. Secondary outcomes will include pain, physical function, psychological factors, quality of life, and cognitive function. Data will be analyzed using descriptive statistics and qualitative thematic analysis. <br/>Discussion(s): The findings will inform the design of a future large-scale randomized controlled trial and contribute to the development of more effective digital interventions tailored to the needs of older adults with chronic musculoskeletal pain. Trial registration: This study is registered on clinicaltrials.gov, NCT07774416 (https://clinicaltrials.gov/study/NCT07774416?tab=study), August 18, 2026.<br/>Copyright © 2026, Oliveira et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided…

Author Names: Sun, F.,Zaman, A.,Huang, R. Database Source: Embase Daily Updates Journal Title: Annals of Epidemiology Article Title: Managing existing pain: Predicting pain progression and improvement using machine learning approaches Year: 2026 Issue: Volume: 124 Abstract: Purpose Chronic pain (CP) is highly prevalent in the U.S. and imposes substantial health and economic burdens. Understanding which biopsychosocial and treatment-related factors drive pain progression and improvement is essential for developing targeted prevention strategies. Methods Using the 2019-2020 National Health Interview Survey Longitudinal Cohort data, we applied Random Forest machine learning algorithms with permutation-based feature importance to predict four one-year pain transitions: nonchronic-to-chronic pain progression, CP-to-high-impact chronic pain (HICP) progression, complete CP improvement (CP to no pain), and partial CP improvement (CP to nonchronic pain). Analyses were stratified by age, sex, race/ethnicity, education, and urban-rural residence. Results Comorbidity count was a universal predictor across all four outcomes and nearly every subgroup. Opioid use ranked first for HICP progression and predicted higher odds of progression. Socioeconomic factors, particularly employment status, ranked highest among older, male, non-Hispanic White, and less-educated adults, whereas social relations ranked highest among racial and ethnic minorities. Predictors shifted from health conditions for CP progression toward pain treatment use and social and economic factors for HICP progression. Conclusions Predictors of pain progression and improvement differ by transition stage and across populations, highlighting the need for equity-informed pain management strategies tailored to population-specific risk profiles.<br/>Copyright © 2026 Elsevier Inc.

Author Names: Barros-Beracaza, E.,Martinez-Rodrigo, E.,Garcia-Garcia, F. Database Source: Embase Daily Updates Journal Title: Health Communication Article Title: Communicative Fractures in Chronic Pain: A Conceptual Model for Health Communication Year: 2026 Issue: Volume: Abstract: Chronic pain is inherently subjective and must become communicable before it can be interpreted, socially recognized, and incorporated into clinical reasoning. Existing scholarship has examined pain expression, interpersonal responses, validation and invalidation, patient-clinician communication, family communication, and communicative disenfranchisement, but these phenomena have often been addressed within partly distinct research traditions. This conceptual article develops and delimits the pain communication fracture model (PCFM) through an integrative synthesis of pain science, health communication, illness narratives, interpersonal validation, communicative disenfranchisement, nocebo research, and pain education. The model distinguishes four analytical communicative registers-bodily experience, communicable expression, interpersonal interpretation, and clinical formulation-and three communicative fractures located in the transformations between them: CF1, expressibility; CF2, interpersonal legitimation; and CF3, clinical translation. The fractures are proposed as analytically distinguishable but potentially overlapping and dynamically interrelated processes, rather than as fixed stages, diagnostic categories, or established causal mechanisms. The PCFM links each fracture to preliminary indicators, plausible consequences, and potential mitigation strategies while accounting for patient agency, legitimate doubt, clinical judgment, and structural constraints. Its proposed contribution is integrative, architectural, and operational, rather than a claim to novelty for previously documented phenomena. The model remains unvalidated, and its value will depend on whether future research demonstrates that the three fractures are observable, sufficiently distinguishable, and useful for understanding chronic pain communication.<br/>Copyright © 2026 Taylor & Francis Group, LLC.

Author Names: Korbani, I.,Valcin, L.,Reagan, L.,Shook, N.J. Database Source: Embase Daily Updates Journal Title: Pain Management Nursing Article Title: Perfectionism and Chronic Pain: A Scoping Review Year: 2026 Issue: Volume: Abstract: Objectives Perfectionism has been implicated in psychological and health problems, but its role in chronic pain remains unclear. This scoping review aimed to map and summarize quantitative evidence of associations between perfectionism and pain-related outcomes. Design Scoping review conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Data Sources PubMed, CINAHL, APA PsycINFO and Scopus. Review/Analysis Method Peer-reviewed, quantitative English-language studies examining perfectionism and chronic or recurrent pain were eligible. Two reviewers independently screened records, extracted data, and completed Joanna Briggs Institute critical appraisal tools. Findings from 15 studies were summarized narratively. Results Maladaptive perfectionism was generally associated with greater pain intensity, functional interference, and adverse cognitive-affective and somatic outcomes. A few studies reported inverse associations, such that greater maladaptive perfectionism was associated with lower pain intensity or less pain catastrophizing. Adaptive perfectionism was examined less often and showed mixed findings. Its unique effects were typically weaker, indirect, or no longer significant after accounting for maladaptive perfectionism or covariates. Conclusions Perfectionism, particularly maladaptive facets, appears more often to function as a vulnerability than a resource in chronic pain. However, conclusions remain tentative because the evidence base is heterogeneous, predominantly cross-sectional, and inconsistent in some areas. Research has also focused disproportionately on maladaptive dimensions, limiting understanding of adaptive perfectionism. Nursing Practice Implications Assessing perfectionism-related tendencies may help clinicians identify patients at risk for cognitive-affective distress, maladaptive activity patterns, and functional interference, supporting more individualized chronic pain assessment and intervention development.<br/>Copyright © 2026 .

Author Names: Trisolini, S.,Toti, A.,Lucarini, E.,Di Cesare Mannelli, L.,Ghelardini, C.,Micheli, L. Database Source: Embase Daily Updates Journal Title: Inflammopharmacology Article Title: Enhancing meloxicam efficacy in acute and chronic inflammatory pain: a novel dose-sparing approach using ultramicronized palmitoylethanolamide Year: 2026 Issue: Volume: Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs), such as meloxicam, are widely used for the management of inflammatory pain in human and veterinary medicine, although their clinical utility is limited by dose-dependent adverse effects. Strategies aimed at reducing NSAID dosage while preserving analgesic efficacy are therefore warranted. We investigated whether ultramicronized palmitoylethanolamide (PEAum), an endogenous prohomeostatic lipid amide with improved bioavailability, could enhance the antinociceptive effects of meloxicam in preclinical models of acute and chronic inflammatory pain. Acute pain was induced by intraplantar lipopolysaccharide (LPS) injection, while chronic pain was induced by intra-articular injection of Complete Freund's Adjuvant (CFA). Mechanical hyperalgesia and allodynia were measured by the Paw pressure and von Frey tests, respectively. In the LPS model, PEAum confirmed its superior anti-hyperalgesic profile compared with micronized and native PEA. PEAum (10 mg/kg) markedly enhanced the analgesic activity of low-dose meloxicam (3 mg/kg), with the combination fully reversing inflammatory hypersensitivity and outperforming high-dose meloxicam (30 mg/kg). In the CFA model, the same association completely counteracted mechanical hyperalgesia, reproducing the antalgic effect of high-dose meloxicam. A pharmacodynamic study demonstrated that pharmacological blockade of PPAR-alpha with the selective receptor antagonist GW6471 (2 mg/kg) significantly reduced, but did not abolish, the analgesic effect of the combination, suggesting both PPAR-alpha-dependent and independent mechanisms. Overall, the combined treatment produced a greater-than-additive antinociceptive effect, demonstrating a synergistic interaction between PEAum and meloxicam in both acute and chronic inflammatory pain. This synergy enables substantial meloxicam dose-reduction while maintaining full analgesic activity, supporting a promising dose-sparing strategy for inflammatory pain management.<br/>Copyright © The Author(s) 2026.

Author Names: Chin, E.,Salib, P.,Collender, L.,Shumaker, S.,Riordan, H.,Campbell, C. Database Source: Embase Daily Updates Journal Title: Developmental Medicine and Child Neurology Article Title: Short-term Impact of Remote Group Cognitive Behavioral Therapy for Chronic Pain for Adults with Cerebral Palsy and Chronic Pain Year: 2026 Issue: Supplement 4 Volume: 68 Abstract: Background and Objective(s): Cognitive Behavioral Therapy (CBT) is a gold standard treatment for chronic pain, but specific benefits in adults with cerebral palsy and chronic pain are unknown. We hypothesize that CBT reduces pain-related impairment by reducing maladaptive thoughts about chronic pain (pain catastrophizing) and improving individuals' abilities to achieve their goals despite pain (pain self-efficacy). In this individually-randomized group treatment pilot trial, we report on short-term efficacy across hypothesized outcomes seeking to identify subpopulations of individuals with cerebral palsy most likely to benefit from CBT for chronic pain. Study Participants & Setting: Adults with cerebral palsy and high-impact chronic pain (interfering at least moderately with at least one aspect of their life in the past day, Brief Pain Inventory) with the ability to communicate effectively (Communication Functional Classification System level <=3) and the cognitive ability to discriminate between thoughts, behaviors, and feelings (>=12/23 Behavior, Thought, Feeling Questionnaire items correct) who could join remote therapy sessions in Maryland were recruited via digital communications and screened for inclusion criteria. We excluded individuals who attributed most of their pain to a recent (<3 months ago) event or had previously completed CBT for chronic pain. Materials/Methods: Following consent, half of participants were randomized to receive CBT immediately following baseline evaluation (0-3 months) and half at 3-6 months. Two licensed social workers with expertise in CBT led 12-week group courses using the Veterans Affairs manual (Murphy et al.). Participants completed online questionnaires querying subjective impacts in Overall Well-being, Physical Activities, Social Activities, Work-related Activities, Mood, and Pain domains (Global Impression of Change), pain catastrophizing (Pain Catastrophizing Scale), and pain self-efficacy (Pain Self-Efficacy Questionnaire-4). Analysis remains blinded to group assignments for this ongoing trial. For this preliminary analysis, we evaluated 0…

Author Names: Kopach, O. Database Source: Embase Daily Updates Journal Title: Bioengineering Article Title: Piezo1 in Peripheral and Central Sensitisation: Implications for Chronic Pain Year: 2026 Issue: 9 Volume: 13 Abstract: Piezo1 is an increasingly recognised mechanosensitive ion channel that transduces mechanical forces into electrical and biochemical signals and is expressed in peripheral sensory pathways as well as across multiple cell types within the central nervous system. Growing evidence indicates that Piezo1 contributes to nociceptive processing by influencing cellular excitability, inflammatory signalling, and neuron-glia interactions within nociceptive circuits. These actions position Piezo1 as an important contributor to amplified nociceptive transmission and circuit hyperexcitability, thereby potentially facilitating the transition from acute to chronic pain via several integrating mechanisms. In this context, Piezo1 may interact with other established mechanisms of chronic pain, including peripheral and central sensitisation and neuroinflammatory signalling, to help sustain persistent pain states. This review examines the potential roles of Piezo1 as a synergistic contributor to nociceptive hyperexcitability and considers how it may modulate nociceptive excitability, glial activation, and central sensitisation. Available findings support the view that Piezo1 participates in mechanotransduction and maladaptive plasticity relevant to chronic pain, although direct evidence for its cell-specific actions within spinal dorsal horn circuits remains limited. Piezo1 has also been implicated in tissue remodelling following spinal cord injury, suggesting that its therapeutic relevance may extend beyond pain signalling alone. Further studies will be required to clarify its mechanistic role in the mechanobiology of chronic pain and to evaluate the translational potential of targeting Piezo1 through pharmacological or genetic strategies for pain management.<br/>Copyright © 2026 by the author.

Author Names: Zorina-Lichtenwalter, K.,Rader, L.,Ceko, M.,Friedman, N.P.,Bango, C.I.,Petre, B.,Wager, T.D.,Lindquist, M.A. Database Source: Embase Daily Updates Journal Title: Pain Article Title: Brain gray matter changes across chronic pain trajectories: MRI evidence from 35,000 individuals Year: 2026 Issue: Volume: Abstract: ABSTRACT: Chronic pain affects brain gray matter structure, but the magnitude, pattern, and reversibility of brain changes upon pain recovery remain unclear because of inconsistent findings from small-scale studies. We analyzed data from 35,052 UK Biobank participants who completed chronic pain assessments at 2 time points, approximately 9 years apart, evaluating pain lasting 3 months or more, across 8 body sites. Brain magnetic resonance imaging data were available from the second time point. Participants were grouped into 4 categories: Pain-free controls, New chronic pain, Persistent chronic pain, and Resolved chronic pain. We examined relationships between these categories and 313 brain-wide measures across cortical surface area, cortical thickness, and subcortical volume. New chronic pain was associated with surface area reductions in sensorimotor, temporo-parietal, and medial and lateral prefrontal cortices. Persistent chronic pain showed larger and more widespread area reductions and mixed changes in cortical thickness and subcortical volumes, including cerebellar atrophy and hypertrophy in the thalamus and basal ganglia. Resolved pain demonstrated reversibility of most brain changes, except sustained surface area reductions in the primary somatosensory cortex. No areas showed effects consistent with a predisposition to pain. Brain structural changes in chronic pain reflect adaptive neuroplasticity rather than irreversible damage or preexisting vulnerability. Most changes appear reversible with pain resolution, underscoring the importance of effective pain treatment to alleviate symptoms and support recovery of brain structure and function.<br/>Copyright © 2026 International Association for the Study of Pain.

Author Names: Schmitz, S.,Lowe, B.,Husing, P. Database Source: Embase Daily Updates Journal Title: BMJ open Article Title: Autonomic imbalance as a predictor of pain expectations and pain experience in chronic back pain: study protocol of a pilot study on the application of heart rate variability biofeedback in a mixed-methods design (BACK.BEAT) Year: 2026 Issue: 9 Volume: 16 Abstract: INTRODUCTION: Chronic back pain is a leading cause of disability worldwide and is increasingly understood as a biopsychosocial condition involving not only nociceptive but also autonomic and cognitive-emotional mechanisms. Dysregulation of the autonomic nervous system, reflected in reduced heart rate variability (HRV), has been identified as a potential biomarker of chronic pain vulnerability. Simultaneously, maladaptive pain expectations can amplify perceived pain and contribute to symptom persistence. HRV-based biofeedback, which aims to restore autonomic balance through paced breathing, represents a promising but underexplored approach to modulating both physiological and psychological aspects of chronic pain. This study aims to examine the relationship between daily HRV patterns, pain expectation and pain experience in individuals with chronic back pain, evaluate the feasibility and effectiveness of HRV biofeedback training in improving HRV and reducing pain and explore potential changes in patients' illness understanding following the intervention. METHODS AND ANALYSIS: The study employs a mixed-method randomised controlled design. Participants with chronic back pain will be randomly assigned to an HRV biofeedback intervention group or a control group. Daily HRV will be continuously monitored using the Garmin Vivosmart 5 smartwatch and correlated with daily pain expectations and experiences. HRV-biofeedback under laboratory conditions will be carried out with the NeXus-4 biofeedback system (MindMedia). Feasibility and acceptability of the study design will be analysed through rates of recruitment, retention, adherence and the suitability of study procedures and outcome measures. Secondary to this, HRV will be analysed using both time- (SDNN, RMSSD) and frequency-domain (lnLF, lnHF) parameters. Pain expectation and daily pain experience will be assessed through ecological momentary assessment. Quantitative analyses will include Pearson/Spearman correlations, repeated-measures analyses of variance (ANOVAs) (GroupxTime) and exploratory regression models. Qualitative data…

Author Names: Silveira Bianchim, M.,Joseph, R.,Boivin, J.,Noyes, J. Database Source: Embase Daily Updates Journal Title: BMJ open Article Title: Use of symptom-reporting tools to support endometriosis identification and management in primary care: a realist synthesis Year: 2026 Issue: 9 Volume: 16 Abstract: OBJECTIVES: Endometriosis affects 5-10% of women of reproductive age and is associated with chronic pain, infertility and reduced quality of life. Symptom Reporting Tools (SRTs) may support identification and management in primary care, but evidence is limited. This review investigates what works, for whom, in what contexts and why, when using SRTs for endometriosis in primary care. DESIGN: A realist synthesis was used to develop programme theories on how SRTs were intended to work for women and healthcare practitioners. DATA SOURCES: A purposive and iterative search was conducted across eight databases (Google Scholar, Press Reader, PubMed, Web of Science, LibrarySearch, APA PsycINFO via Ovid, Overton and Scopus) between January and April 2024 and updated in October 2025. ELIGIBILITY CRITERIA: Studies were included if they focused on women, primary care professionals or SRT developers, and addressed symptom tracking, shared decision-making and diagnostic delays. Studies from low- and middle-income countries, non-English language or lacking SRT content were excluded. DATA EXTRACTION AND SYNTHESIS: Initial programme theories of how SRTs were intended to work for women and healthcare practitioners were developed, tested and refined with stakeholder and patient and public involvement and engagement. <br/>RESULT(S): This review included 102 studies: 83 informing initial theory development and 19 were used to refine these theories, covering a total of 22 266 participants aged between 13 and 70 years. Most studies included in the synthesis were cross-sectional (n=15). Evidence showed that independent SRT use could enhance symptom awareness, health literacy, self-management and quality of life. During appointments, SRTs might support communication and personalised treatment, potentially leading to more timely diagnosis and improved outcomes. However, without guidance, SRT use could also cause distress and disempowerment. Challenges included symptom variability and limited awareness of endometriosis and SRTs in primary care. Few studies explored the experiences of those unaware their symptoms could indicate endometriosis. <br/>CONCLUSION(S): Our findings…

Author Names: Esteves, M.,Bernardo, S.,Cunha, A.M.,Leite-Almeida, H. Database Source: Embase Daily Updates Journal Title: Article Title: Executive Functions in Chronic Pain Models Year: 2026 Issue: Volume: 235 Abstract: Assessment of pain and its impact in chronic pain models is challenging. Evoked responses to noxious and innocuous stimuli have been typically used. However, in the past two decades, it became evident that manifestations of anxiety- and depressive-like behaviors as well as cognitive dysfunction can broaden the characterization of pain impact in preclinical research. Executive functions comprise a set of cognitive control processes including working memory, inhibitory control, and cognitive flexibility. Despite the well-known structural and functional impact of chronic pain on frontal cortical and subcortical structures that subserve executive functions, these remain poorly studied in the context of preclinical chronic pain studies. In this chapter, we describe two behavioral paradigms-variable delay-to-signal (motor impulsivity and delay intolerance) and habit-based to goal-directed decision-making-and their respective protocols. Our goal is to provide a step-by-step guide to assist the implementation of the paradigms and interpretation of their results and limitations.<br/>Copyright © The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2026.

Author Names: Marin, A.J.V.,Rodriguez, L.A.,Sanchez-Garcia, M.A. Database Source: Embase Daily Updates Journal Title: Article Title: Intrathecal Drug Delivery for Chronic Pain Year: 2026 Issue: Volume: 234 Abstract: Chronic pain is highly prevalent and disabling, demanding therapeutic strategies that deliver meaningful analgesia while minimizing systemic toxicity. This chapter reviews intrathecal drug delivery (IDD) as a mature form of chemical neuromodulation for refractory cancer and non-cancer pain, tracing its historical development from early spinal anesthesia and single-shot neuraxial opioids to contemporary fully implantable infusion systems. We outline the conceptual framework of neuromodulation, distinguish surgical from non-surgical approaches, and situate IDD within multidisciplinary pain pathways. Technical elements of modern systems are detailed, including intrathecal catheters, fixed-flow versus programmable pumps, and programming paradigms, with practical comparisons among commonly used devices. Indications, contraindications, and rigorous patient selection are synthesized into a structured pre-implant evaluation that integrates psychological assessment, trialing strategies, and shared decision-making, with separate pathways for cancer-related and chronic non-cancer pain. Pharmacology focuses on agents with the strongest intrathecal evidence-morphine and ziconotide-as well as adjuvants such as bupivacaine and clonidine, emphasizing pharmacokinetics, dosing ranges, stability, and combination rationales. Complications are reviewed across surgical, device-related, and pharmacologic domains, including CSF leakage, infection, catheter malfunction, granuloma formation, overdose, and withdrawal; diagnostic cues and stepwise management algorithms are provided. Finally, we consider future directions that converge on greater precision and safety: smarter pumps and remote monitoring, MRI-aware designs, human-factor improvements to refill and programming workflows, novel non-opioid intrathecal agents, and biomarker-guided personalization alongside synergistic combinations with electrical neuromodulation and rehabilitation. Taken together, intrathecal analgesia emerges as a durable, titratable, and cost-aware option for carefully selected patients, provided it is delivered within a disciplined perioperative framework and longitudinal stewardship that anticipates complications and adapts therapy to evolving clinical goals.<br/>Copyright © The Author(s),…

Author Names: Jensen, M. P.,Flaster, A. P.,Humbert, A.,Mendoza, M. E.,Sugarman, L. I.,Gottlieb, O. Database Source: APA PsycInfo <October 2026 Week 4> Journal Title: International Journal of Clinical and Experimental Hypnosis Article Title: Digital interactive media for chronic low back pain management: A feasibility study. Year: 2026 Issue: Volume: Abstract: Chronic pain is common and is associated with significant costs and suffering. Therapeutic hypnosis has shown promise as an effective chronic pain treatment, but access to this intervention is extremely limited. Digital applications that offer therapeutic hypnosis, if found to be effective, could address this access problem. The primary aim of the current paper is to describe the results of two studies (Study 1 = individuals with low back pain; Study 2 = individuals with mixed chronic pain conditions) conducted to evaluate the feasibility of the digital hypnosis interactive media application for providing therapeutic hypnosis. Fifty participants in both studies were randomly assigned to one of two groups: (1) 8 weeks of access to the application or (2) 4 weeks of no access followed by 4 weeks of access. Five feasibility and eight clinical outcomes were assessed. The findings indicate that the application is feasible, and that additional work to develop and evaluate the application is warranted. Both studies were prospectively registered at ClinicalTrials.gov (Identifier: NCT06050083). (PsycInfo Database Record (c) 2026 APA, all rights reserved),,Abstract (French),Medias numeriques interactifs pour la prise en charge des lombalgies chroniques : une etude de faisabiliteMark P. Jensen, Aaron P. Flaster, Andrew Humbert, M. Elena Mendoza, Laurence I. Sugarman et Owen GottliebResume: La douleur chronique est frequente et s'accompagne de couts importants et de souffrances considerables. L'hypnose therapeutique s'est revelee prometteuse en tant que traitement efficace de la douleur chronique, mais l'acces a cette intervention est extremement limite. Les applications numeriques proposant de l'hypnose therapeutique, si leur efficacite est demontree, pourraient remedier a ce probleme d'acces. L'objectif principal du present article est de decrire les resultats de deux etudes (Etude 1 = personnes souffrant de lombalgie ; Etude 2 = personnes souffrant de diverses pathologies douloureuses chroniques) menees afin d'evaluer la faisabilite d'une application interactive d'hypnose numerique pour la pratique de l…

Author Names: Nagamine, T. Database Source: APA PsycInfo <October 2026 Week 3> Journal Title: Innovations in Clinical Neuroscience Article Title: Gut microbiota as a therapeutic target for chronic pain disorders. Year: 2026 Issue: 1-3 Volume: 23 Abstract: Chronic pain disorders of unknown etiology, including burning mouth syndrome, chronic pelvic pain, fibromyalgia, irritable bowel syndrome, myofascial pain syndrome, and temporomandibular joint disorders, have been demonstrated to result in a substantial reduction in quality of life. These diseases exhibit a discernible gender bias, manifesting with greater frequency in women. The neurobiological underpinnings of these conditions are characterized by a decline in the volume of white matter in the medial prefrontal cortex and alterations in the connectivity of the default mode network. These conditions are frequently linked to impaired function of the central dopaminergic nervous system. The potential mechanisms connecting the gut microbiota to chronic pain disorders may be the decrease in butyrate-producing bacteria in dopamine signaling and the change in estrobolome in estrogen signaling. Consequently, an approach targeting the gut microbiota using probiotics has emerged as a potential treatment for chronic pain disorders. (PsycInfo Database Record (c) 2026 APA, all rights reserved)

Author Names: Willman, J. Database Source: APA PsycInfo <October 2026 Week 3> Journal Title: Dissertation Abstracts International: Section B: The Sciences and Engineering Article Title: Impact of Eye Movement Desensitization and Reprocessing to improve pain and function in chronic pain patients. Year: 2026 Issue: 12-B Volume: 87 Abstract: Chronic pain is often linked to a history of psychological trauma. The symptoms of pain are usually challenging to treat and resolve in this patient population, partly due to the body's creation of a maladaptive response to the traumatic event. Despite the high correlation of chronic pain and trauma, screening for trauma in chronic pain management settings is not a common occurrence. The absence of this screening could create barriers to adequate treatment for trauma and its associated somatic symptoms. Eye Movement Desensitization and Reprocessing (EMDR) therapy, a psychotherapy used to treat trauma and posttraumatic stress disorder, has shown positive results in reducing pain intensity in this population. The purpose of this DNP project was to determine the impact of EMDR on pain and function in chronic pain patients with a history of trauma. The interventions included screening for trauma and the implementation of EMDR therapy through weekly or biweekly sessions, completing the eight phases of the therapy. The project did not yield statistically significant results for pain intensity, physical function, or coping, but positive outcomes were observed among several participants. Despite not yielding statistically significant results in pain intensity, physical function, or coping, positive outcomes were still noted among the participants. Some patients did have reduced pain scores from baseline, and a few were able to return to work. This DNP project demonstrated the importance of trauma-focused care in pain management settings. (PsycInfo Database Record (c) 2026 APA, all rights reserved)

Author Names: Talyshinskii, A.,Kudakova, F.,Staroseltseva, O.,Gadzhiev, N.,Somani, B.K. Database Source: Embase Daily Updates Journal Title: Diagnostics Article Title: Artificial Intelligence in the Assessment of Males with Chronic Pelvic Pain Syndrome: An Up-to-Date UPOINTS-Based Narrative Mapping Review Year: 2026 Issue: 15 Volume: 16 Abstract: Background/Objectives: Male chronic pelvic pain syndrome (CPPS) is a heterogeneous condition involving overlapping urinary, psychosocial, organ-specific, infectious, neurological, myofascial, and sexual phenotypes. This complexity limits the effectiveness of routine symptom assessment and empirical treatment strategies. Artificial intelligence (AI) may support more reproducible interpretation, differential diagnosis, phenotyping, and personalized management. This up-to-date narrative mapping review aimed to identify AI-assisted approaches that are directly or indirectly relevant to the assessment of males with CPPS, classify them according to UPOINTS phenotypic domains and clinical functions, and critically discuss the extent to which current evidence is disease-specific or extrapolated from related conditions. <br/>Method(s): A literature search was performed in PubMed/MEDLINE, the Cochrane Library, and Google Scholar from database inception to May 2026 using terms related to male CPPS, UPOINTS domains, diagnosis, treatment, prognosis, digital solutions, artificial intelligence, machine learning, deep learning, natural language processing, computer vision, and decision support. Studies were included if they described AI-based or AI-adjacent computational approaches relevant to male CPPS or to related conditions important for UPOINTS-based phenotyping, differential diagnosis, or phenotype-specific assessment. <br/>Result(s): Available evidence remains fragmented and is largely extrapolated from related urological, chronic pain, pelvic floor, infectious, neurological, and sexual medicine conditions. AI applications were most developed in urinary and organ-specific domains, including uroflowmetry analysis, bladder volume assessment, cystoscopy, prostate imaging, urinary biomarkers, and differential diagnosis of lower urinary tract disorders. AI tools also showed potential for infection detection, psychosocial screening, chronic pain monitoring, neuroimaging-based phenotyping, pelvic floor dysfunction assessment, and evaluation of sexual dysfunction. However, male-CPPS-specific validation remains limited. <br/…

Author Names: Database Source: Embase Clinical Trials Journal Title: clinicaltrials.gov Article Title: Effects of Virtual Walking on Chronic Pain and Psychological Distress for Individuals With Severe Mobility Impairment: A Pilot Randomized Controlled Trial and Electroencephalogram Study Year: 2026 Issue: Volume: Abstract: Brief Summary,This randomized controlled trial aims to: (1) examine the effects of virtual walking intervention on chronic pain (primary outcome), and on depression, stress, anxiety, and quality of life (secondary outcomes) compared with the passive observing video control group in individuals with SMI (primarily spinal cord injury and post-polio); (2) explore the neurological mechanism of virtual walking intervention using the resting-state and task-based electroencephalography (EEG); (3) understand their perceived effects, strengths, and limitations for the virtual walking intervention using semi-structured focus group interviews.,Detailed Description,Background: Severe mobility impairment (SMI) negatively impacts lifespan and quality of life, especially through chronic pain and emotional issues such as depressive symptoms. Researchers have developed treatments including pharmacological interventions, physical activities, complementary and alternative medicine, and psychological treatment to treat chronic pain and emotional issues. However, these approaches have limitations. Virtual walking interventions utilize arm-swing locomotion to create the illusion of walking, allowing individuals to experience walking in virtual natural scenes. These interventions have shown feasibility and preliminary effects on mood and pain reduction in people with spinal cord injury. However, prior work varies in locomotion design (e.g., passive observing, trigger-based, or arm-swing), dosage (session length and total dose), and a few studies incorporate objective biomarkers like EEG to test neurological mechanisms. Thus, this study aims to examine the effects of virtual walking on chronic pain and psychological distress and to explore the neurological mechanisms of virtual walking using the resting-state and task-based EEG. <br/>Design(s): This study will be a single-blind, two-arm, parallel-group pilot randomized controlled trial (RCT). Participants and Subgroup Stratification: Forty-eight participants experiencing chronic pain will be recruited from the Hong Kong Polytechnic University. At baseline, all recruited participants will be screened for…

Author Names: Plummer, K.,Takashima, M.,Richards, J.,Mitchell, A.E.,De Young, A.,Herbert, A.,Jibb, L.,Thailek, T.,Meikle, B.,Griffin, B.,McCarthy, M. Database Source: Embase Daily Updates Journal Title: Pain Article Title: Psychosocial interventions for reducing pain and pain-related distress in infants, children, and adolescents undergoing cancer treatment: a systematic review and meta-analysis of randomized control trials Year: 2026 Issue: 11 Volume: 167 Abstract: Pain is a significant burden for children undergoing cancer treatment. Psychosocial interventions offer low-risk strategies to reduce pain and distress. This systematic review and meta-analysis evaluated their effectiveness during paediatric cancer treatment. Six databases and trial registries were searched from inception to November 2025. Eligible studies were randomized controlled trials delivered during cancer treatment or procedures. Outcomes included child self-reported and parent proxy ratings of pain intensity and pain-related distress. We screened 2674 records and included 42 trials involving 2167 children. Most targeted acute procedural pain (k = 35). Twenty-seven trials were included in meta-analysis. Psychosocial interventions reduced child-reported pain intensity (standardised mean difference [SMD] -0.86, 95% confidence interval [CI] -1.35 to -0.37). Moderate-to-large effects were observed for hypnosis, distraction, and mind-body strategies, with moderate effects for technology-based interventions. Cognitive behavioural therapy showed no effect. Significant reductions were observed for child-reported anxiety (SMD -1.54, 95% CI -1.84 to -1.24). Effects on fear and global distress were variable. Parent proxy reports showed reduced postprocedural pain (SMD -0.77, 95% CI -1.36 to -0.18), with inconsistent effects for distress. Risk of bias was low in 17% of trials, with most demonstrating methodological concerns. No adverse events were reported. Evidence remains concentrated in procedural contexts, with limited evaluation of treatment-related or chronic pain. Infants and children with neurocognitive impairment were underrepresented. Psychosocial interventions are associated with reductions in paediatric cancer pain and anxiety. Future multisite trials should extend evaluation across the cancer trajectory and prioritise inclusive designs. PROSPERO registration: - CRD42022343066.<br/>Copyright © 2026 International Association for the Study of Pain

Author Names: Sinha, C.,Nunez, M.A.,Bai, S.,Batts, K.W.,Myer, G.,Kesar, T.,Sil, S.,Mooney, J.,Adkins, T.,Dampier, C.,Williams, J.,Crosby, L.,Thomas, S.,Beasley, K.,Murphy, B.,Kurzhals, A.,Quinn, C.,Kashikar-Zuck, S.,Lang, A.,Bakshi, N. Database Source: Embase Daily Updates Journal Title: British Journal of Haematology Article Title: I-STRONG: Development and pilot of an interdisciplinary, multicomponent treatment approach for pediatric chronic SCD pain Year: 2026 Issue: Supplement 1 Volume: 209 Abstract: Introduction: Chronic pain affects about 20% of adolescents living with sickle cell disease (SCD), contributing to impaired quality of life and daily functioning. Clinical guidelines suggest the need for individualized chronic SCD pain management that integrates pharmacological and nonpharmacological treatment approaches. Yet, evidence-based interdisciplinary approaches for chronic SCD pain treatment are lacking. We aimed to (1) utilize community engagement to adapt an integrative multicomponent treatment program designed to meet the unique needs of chronic SCD pain (I-STRONG for SCD), and (2) optimize feasibility and acceptability of I-STRONG through a proof-of-concept pilot trial. <br/>Method(s): An existing treatment protocol for fibromyalgia that combines cognitive-behavioral therapy (CBT) for pain and neuromuscular exercise training was modified for chronic SCD pain to develop I-STRONG. Modifications were informed by semi-structured qualitative interviews with adolescents (12-18 years old) with chronic SCD pain (n= 12) and their caregivers (n= 12), community advisory boards, and interdisciplinary experts representing hematology, psychology, physical therapy, rehabilitation medicine, and sports medicine. I-STRONG is a virtual 8-week, 16-session, group intervention combining CBT and neuromuscular exercise training, co-led by experts in psychology and physical therapy. A pilot clinical trial of I-STRONG (n= 12 adolescents, n= 9 caregivers) was conducted to iteratively optimize feasibility and acceptability. Primary outcome was typical pain intensity assessed at baseline, post-treatment, and 3-month follow-up (primary endpoint). Patient global impression of change in pain was assessed at post-treatment and follow-up. <br/>Result(s): Adolescents were on average 16.3 years, 42% female, and 100% Black/African American; caregivers were on average 40.8 years, 100% female, and 89% Black/African American. Community engagement strategies informed systematic…

Author Names: Riemer, J.,Wang, J. Database Source: Embase Daily Updates Journal Title: Pediatric Rheumatology Article Title: The experience of acupuncture: patient reported outcome benefits of acupuncture treatment alongside standard non-pharmacological treatment in the management of paediatric chronic pain. A preliminary qualitative study Year: 2026 Issue: Supplement 1 Volume: 24 Abstract: Introduction Chronic pain affects up to 30% of children and adolescents and is associated with significant physical, emotional, and social impairments. While multidisciplinary non-pharmacological interventions remain the cornerstone of treatment, acupuncture is increasingly used as an adjunctive therapy. However, there is limited evidence exploring patient-reported experiences and perceived benefits of acupuncture within paediatric chronic pain services. This study aimed to investigate the lived experiences, acceptability, and perceived outcomes of acupuncture alongside standard care in children and adolescents with chronic pain. Objectives To explore how children and adolescents describe their experiences of acupuncture within a multidisciplinary chronic pain service. To identify patient-reported physical, emotional, and functional outcomes associated with acupuncture treatment. To examine how acupuncture complements other non-pharmacological interventions. To generate thematic insights into the perceived value, mechanisms, and acceptability of acupuncture from the patient perspective. Methods A qualitative service evaluation was conducted within a UK NHS specialist paediatric chronic pain service. Seven participants aged 10-18 years with primary chronic pain who had received acupuncture were purposively recruited. Semi-structured interviews were conducted immediately post-treatment, focusing on treatment experiences, symptom changes, acceptability, and integration with wider care. Interviews were audio-recorded, transcribed verbatim, and analysed using reflexive thematic analysis following Braun and Clarke's six-phase framework. Results Participants described acupuncture as a calming and acceptable intervention that supported emotional regulation, improved sleep, and provided variable symptom-specific pain relief. Seven themes emerged: relaxation, sleep improvement, differentiated pain relief, tolerable sensory experiences, practitioner communication, flexible parental involvement, and treatment environment. Communication, predictability, and supportive practitioner…

Author Names: White, J.N.,Angst, M.S.,Gaudilliere, B.,Aghaeepour, N.,Simons, L.E.,King, C.D.,Coghill, R.C.,Lopez-Sola, M.,Moayedi, M.,Stinson, J.N. Database Source: Embase Weekly Updates Journal Title: Pain Article Title: Identification of high-impact chronic pain in adolescents with musculoskeletal pain Year: 2026 Issue: 10 Volume: 167 Abstract: Abstract - High-impact chronic pain (HICP) describes pain that interferes substantially with daily functioning and is associated with diminished quality of life, yet brief tools to identify and track HICP in adolescents are lacking. The 3-item Pain, Enjoyment, and General Activity (PEG) scale derived from the Brief Pain Inventory offers a promising rapid measure, but its psychometric properties and an empirically derived HICP cut-off score based on PEG have not been established in pediatric chronic pain. The present study examined convergent validity, classification accuracy, and a PEG cut-off for HICP in 263 adolescents (10-18 years; 84.4% female) with chronic musculoskeletal pain receiving tertiary pain care. The PEG was strongly associated with primary clinical variables: functional disability (r = 0.63), quality of life (r = -0.56), and pain intensity and unpleasantness (r = 0.58, 0.61), and strongly-to-moderately associated with secondary clinical variables: fatigue (r = 0.53), depression (r = 0.49), and pain catastrophizing (r = 0.49), with modest associations with sleep and anxiety (r = -0.31, 0.25). Receiver operating characteristic analysis indicated that across all 4 primary clinical variables, the PEG demonstrated the strongest discrimination of upper-tertile functional disability scores (Functional Disability Inventory >=28, area under the curve = 0.81, sensitivity 0.75, specificity 0.76, positive predictive value 0.64, Youden index 0.51, PEG score cut-off 6) and was cross-validated against pain intensity, pain unpleasantness, and quality-of-life variables. The PEG represents a promising brief monitoring and clinical status tool to support risk-stratified care and clinical research in pediatric chronic musculoskeletal pain.<br/>Copyright © 2026 The Author(s). Published by Wolters Kluwer Health, LLC. on behalf of the International Association for the Study of Pain.

Author Names: Parker, J.A.,Cormier, B.,Dol, J.,Chambers, C.T.,Birnie, K.A. Database Source: Embase Preprint Journal Title: medRxiv Article Title: Chronic Pain in Canadian Children and Adolescents: A National Population-Based Analysis Year: 2026 Issue: Volume: Abstract: Background: Chronic pain affects approximately 20% of children and youth worldwide and is associated with mental and physical health impacts. Canada-specific data on the prevalence of chronic pain in children and youth are limited, highlighting the need for current high-quality population-based estimates Aims: The aim of this study is to provide national estimates of self-reported chronic pain among Canadian children and youth by pain type (headache stomach ache, backache), sex (female, male), age group (5-11, 12-17 years) and province or territory. <br/>Method(s): Publicly available data were used from the 2019 Canadian Health Survey on Children and Youth (CHSCY), a population-based survey conducted by Statistics Canada using a nationally representative sample of Canadian children and youth Results: Overall, headaches were the most commonly reported pain type (15.4%), followed by stomach aches (12.5%), and backaches (11.1%). Prevalence was consistently higher among females than males and among youth than children, with youth girls reporting the highest prevalence across all pain types. Prevalence also varied geographically, with some of the highest estimates observed in the Atlantic Provinces. <br/>Conclusion(s): Chronic pain affects substantial proportions of Canadian children and youth with disparities observed by pain type, sex, age, and geography. These findings under score pediatric chronic pain as an important public health issue and highlight the need for equity-oriented approaches that address the needs of populations experiencing the greatest burden.<br/>Copyright © 2026, Posted by openRxiv

Author Names: Ravyts, S.G.,Rosado, E.C.,Persin, M. Database Source: Embase Daily Updates Journal Title: Journal of Clinical Medicine Article Title: The Unique and Joint Associations of Childhood and Recent Life Stressors on Chronic Pain Symptoms Year: 2026 Issue: 18 Volume: 15 Abstract: Background/Objectives: Early life stress is a well-established predictor of chronic pain; however, less is known about whether early and recent life stressors interact to influence chronic pain. The purpose of the present study was to examine the unique and joint associations of early and recent life stressors on chronic pain symptoms and examine whether general sensory sensitivity mediates the association between stress exposure and pain-related symptoms. <br/>Method(s): Participants included 577 adults from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP-II) Symptoms Pattern Study. Early life stressors (ELSs) and recent life stressors (RLSs) were examined using the Childhood and Recent Traumatic Events Scale, while general sensory sensitivity and pain symptoms were measured using the Complex Medical Symptoms Inventory and the Brief Pain Inventory. <br/>Result(s): The interaction between ELSs and RLSs significantly predicted pain severity (beta = 0.25, p = 0.01) and distribution (beta = 0.25, p = 0.02); these results remained significant even after controlling for sociodemographic characteristics. By contrast, ELSs (beta = 0.15, p = 0.04) and RLSs (beta = 0.16, p = 0.02) uniquely predicted pain interference. Moderated mediation models indicated that RLSs moderated the effect of ELSs on general sensory sensitivity, but there was no evidence of an indirect association with pain-related outcomes. <br/>Conclusion(s): Consistent with the early life sensitization model of stress, the interaction between ELSs and RLSs is associated with worse pain-related symptoms. Additional research is needed to better understand the mechanisms through which stress exposure influences chronic pain.<br/>Copyright © 2026 by the authors.

Author Names: Healy, P.,Della Pasqua, O.,Felisi, M.,Ceci, A. Database Source: Embase Daily Updates Journal Title: British journal of clinical pharmacology Article Title: Gabapentin as an add-on analgesic to morphine in paediatric patients with chronic pain Year: 2026 Issue: Volume: Abstract: AIMS: Off-label use of gabapentin for the treatment of chronic pain in children has increased over the last decade, with multiple clinical trials evaluating its role pain management and potential opioid-sparing effects. To date, however, these studies appear to rely on empirical evidence without further consideration of pharmacokinetic-pharmacodynamic principles. Here, we use clinical trial simulations and apply extrapolation concepts to identify dosing regimens of morphine and gabapentin in children that correlate with effective analgesia. <br/>METHOD(S): Simulation scenarios were based on a clinical study (NCT03275012) aimed at the evaluation of the efficacy of gabapentin-morphine combination vs. morphine alone in a paediatric cohort (n = 66, aged 3 months to 18 years). Concentration vs. time profiles of morphine and gabapentin in the target paediatric population were derived using established population pharmacokinetic models. AUC, Cmax and Css were used as metrics of exposure across the titration and maintenance phases of therapy. <br/>RESULT(S): Morphine doses titrated from 0.6 to 1.2 mg/kg/day resulted in concentrations within established analgesic ranges (Cmax: 36.3-82.0 ng/mL; Css: 8.5-19.5 ng/mL). Add-on gabapentin can be titrated in a stepwise manner from 5 up to a maximum of 63 mg/kg. At the maximum dose, median exposure (AUC0-8) corresponded to approximately 35 mg/L.h (i.e., 1200 mg/day adult dose equivalent). <br/>CONCLUSION(S): A weight-banded dosing regimen results in consistent exposure to gabapentin and morphine across different age groups while ensuring acceptable safety margins. In addition, these results offer a rational basis for future clinical trials aiming to reduce opioid burden and optimize pain control in children.<br/>Copyright © 2026 The Author(s). British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

Author Names: Reschke, F.,Toenne, R.,Scheer, M.,Weigel, C.,Glowacka, M. Database Source: Embase Daily Updates Journal Title: Journal of pain and symptom management Article Title: Transdermal Buprenorphine for Pain in Pediatric Palliative Care: A 23-Patient Retrospective Study Year: 2026 Issue: Volume: Abstract: BACKGROUND: Pain management in pediatric palliative care is challenging, particularly in children with neurological impairments, feeding difficulties, or low opioid requirements. Transdermal buprenorphine offers pharmacological advantages, including stable plasma concentrations and a reduced risk of sedation; however, its use in children remains off-label and insufficiently studied. AIM: To evaluate the use, effectiveness, and safety of transdermal buprenorphine in pediatric palliative care and assess its feasibility in everyday clinical practice. DESIGN: Retrospective observational study. Data were extracted from structured electronic medical records, including patient characteristics, analgesic indications, buprenorphine dosing and titration, clinical outcomes, and adverse effects. SETTING/PARTICIPANTS: The study included 23 pediatric patients aged 8 months to 17 years treated between April 2023 and April 2025. Participants received care either from a specialized outpatient pediatric palliative care service (SOPPC; German: Spezialisierte Ambulante Palliativversorgung fur Kinder und Jugendliche, SAPV-KJ; 74%) or an inpatient pediatric palliative care unit. All patients received transdermal buprenorphine for chronic pain. Those treated with other forms of buprenorphine or alternative opioids were excluded. <br/>RESULT(S): All patients initiated treatment with a 5 microg/h patch; 43% required dose escalation. Pain control was rated as good in 87% (95% CI: 66-96%). Improved alertness was observed in 74% (95% CI: 52-88%). Mild local skin reactions occurred in 13%, and no serious adverse events were reported. Sublingual buprenorphine was used effectively for breakthrough pain in 26% of cases. Four patients were managed with transdermal buprenorphine monotherapy. <br/>CONCLUSION(S): Transdermal buprenorphine appears to be an effective and well-tolerated analgesic option for pediatric palliative care patients with low opioid needs. Its ease of use and favorable side effect profile support its potential clinical utility. Prospective studies are warranted to confirm safety and guide dosing strategies.<br/>Copyright © 2026 Elsevier Ltd. All rights reserved.

Can J Pain. 2026 Oct 15;10(1):2717605. doi: 10.1080/24740527.2026.2717605. eCollection 2026. ABSTRACT iCanCope™ (ICC) is a digital self-management program for 15-25 year olds with chronic pain. This study evaluated program satisfaction and efficacy through a two arm randomized controlled trial in Canadian tertiary care pain clinics. Participants were randomized to receive either ICC (app and website with symptom tracking and trending, pain education, goal setting, library, community forum) or an identically branded active control program with limited features. Outcomes were assessed at baseline, postprogram (2 months; T2), and follow-up (6 months; T3). Satisfaction was assessed using the Acceptability eScale and qualitatively with a subset of intervention participants. Linear mixed effects models characterized treatment effects on primary (pain interference) and secondary outcomes. Of 302 enrolled participants, 297 were analyzed (mean age = 17.1 ± 2.4, 83% female). Outcome completion rates were 89% at T2 and 71% at T3. Program acceptability was high in both the intervention (33.9 ± 7.0) and control group (32.7 ± 6.8). Most participants exhibited moderate to high engagement with daily checkins (intervention: 79%, active control: 80%). No significant treatment effects were found. However, improvements across time in pain interference at T2 (β = -0.58, p < .001) and T3 (β = -0.64, p = .0016) and improvements in knowledge about managing pain at T2 (β = -0.54, p < .0001) and T3 (β = -1.04, p < .0001) were found for both groups. Most (15/16) interviewees reported that ICC enhanced their confidence and/or ability to engage in pain self-management. Digitally mediated symptom tracking and trending and pain education is engaging and beneficial for 15-25 year olds with chronic pain. Use of an active-control may have diminished the ability to detect treatment-group effects. ICC has been translated to French-Canadian and publicly released as a free self-management tool. Trial Registration : ClinicalTrials.gov, NCT02601755. PMID: 42899170 | PMC: PMC13679339 | DOI: 10.1080/24740527.2026.2717605

J Pain. 2026 Oct 8:106460. doi: 10.1016/j.jpain.2026.106460. Online ahead of print. ABSTRACT Youth with chronic pain often experience impairments in social functioning; however, research is limited on social treatments targeting connectedness. Previously, adolescents with chronic pain voiced a need for group peer support (GPS) and broadly outlined what they believe is needed in a GPS program. GPS literature gaps remain including: 1) what other important key interest-holders perceive is needed and 2) feedback on a specific/proposed program (vs. what is needed in general). We obtained the perspectives of adolescents with chronic pain, caregivers, and healthcare professionals regarding two proposed formats (i.e., in-person and virtual) of a GPS program. Data were collected through semi-structured virtual interviews and analyzed using deductive and then inductive content analysis. Participants (N = 25; 9 adolescents with chronic pain, 7 caregivers, 9 healthcare professionals) felt positively about the GPS program overall, especially its focus on building social connections, and emphasized how such a patient-oriented program would fill a gap. There were minimal aspects of the proposed program's content and design that were seen as unfavorable; most recommendations focused on improvements to support connection building and the comfort of adolescents. Most participants preferred an in-person GPS program. Study findings provide insights from key interest-holders that will inform the refinement of a GPS program prior to piloting. Ultimately, creating and evaluating a GPS program for adolescents with chronic pain would provide evidence on socially-targeted treatments with the potential to improve the quality of life of adolescents with chronic pain. PERSPECTIVE: This article presents the perspectives of youth, caregivers, and clinicians about what is needed in a group peer support program to help adolescents with chronic pain feel less alone in their experiences and develop friendships. This program's intentional, patient-centered, design could help to fill a gap in the social needs of adolescents with chronic pain. PMID: 42849592 | DOI: 10.1016/j.jpain.2026.106460

Author Names: Wallwork, Sarah B,Hechler, Tanja,Feneberg, Anja C,Hood, Anna M,Mychasiuk, Richelle,Madden, Victoria J,Berryman, Carolyn,Noel, Melanie,Moseley, G. Lorimer Database Source: APA PsycInfo <September 2026 Week 3> Journal Title: Clinical Psychology Review Article Title: Building resilience to chronic pain during childhood: The Situate - Experience - Learn - Feel (SELF) Framework. Year: 2026 Issue: Volume: 125 Abstract: Chronic pain is a significant global public health problem affecting 1 in 4 adults and 1 in 5 young people. Despite the high prevalence of chronic pain, research into its prevention is scarce. In this review, we draw from current, interdisciplinary evidence to present a conceptual Situate-Experience-Learn-Feel (SELF) Framework that takes a developmental and biopsychosocial-societal approach to building children's resilience against future chronic pain. The SELF Framework considers the impact of one's Situation, including social and societal supports and structures, early life Experiences, Learning of skills and knowledge, and the ability to understand and differentiate Feelings, in establishing SELF-empowerment, SELF-enablement, and SELF-reliance for the management of future pain experiences. We argue that childhood (~0-10 years) is a developmental period that provides a potentially critical and thus far untapped opportunity to build resilience to chronic pain in adolescence and beyond. Our framework has three pillars: (1) LEARN: 'Building Knowledge and Skills'-targets children's understanding of pain and healthcare and associated behaviours; (2) EXPERIENCE: 'Strengthening Social Support and Building Emotional Resilience'-targets the fostering of social supports, community, positive childhood experiences, and emotional wellbeing; and (3) FEEL: 'Building Brain-Body Integration'-targets the development and maintenance of movement, interoception, and body awareness. For each pillar, we present its definition and scope, an evidence-based rationale, and provide implementation strategies that could reduce the risk of chronic pain in the future. Importantly, the SELF Framework considers that disadvantageous aspects of a child's broader societal/structural and social SITUAT[ION] may demand additional supports to mitigate risk, and we present several avenues for future research on this. (PsycInfo Database Record (c) 2026 APA, all rights reserved)

Author Names: Betting, Kathrin,Laekeman, Marjan,De Kooning, Margot,Carvalho, Gabriela Ferreira Database Source: APA PsycInfo <August 2026 Week 5> Journal Title: Disability and Rehabilitation: An International, Multidisciplinary Journal Article Title: Critical appraisal of pediatric pain education materials and the integration of lifestyle factors: A scoping review. Year: 2026 Issue: 12 Volume: 48 Abstract: Purpose: Children and adolescents with chronic pain experience lasting impacts on quality of life, often persisting into adulthood. Inadequate lifestyle factors (LSFs) such as physical inactivity, stress, poor sleep, and unhealthy nutrition can worsen pain severity. This scoping review assesses the extent to which LSFs are addressed in pediatric pain education materials and provides recommendations. Materials and methods: A literature review was conducted across six databases, targeting children and adolescents (ages 6-19) receiving pain education. Educational materials were screened for LSFs and critically appraised for understandability and actionability. <ovid:br/>Results: Sixteen studies and 13 educational materials were analyzed. While materials showed good understandability, they lacked sufficient actionability. LSFs, particularly physical activity and stress, were incorporated into pain education. Content was found in seven materials for physical activity, one for screen time, four for sleep, seven for stress, and two for nutrition. Recommendations for improving physical activity were found in eight materials, reducing screen time in one, improving sleep in four, reducing stress in five, and improving nutrition in three. <ovid:br/>Conclusion: Available educational materials do not comprehensively address LSFs or provide actionable strategies for change. More studies are needed to reach a consensus on recommendations and integrate them into educational materials. (PsycInfo Database Record (c) 2026 APA, all rights reserved)

Author Names: Payne, Laura A [Ed] Database Source: APA PsycInfo <August 2026 Week 4> Journal Title: Article Title: Psychosocial interventions for chronic pain in women and girls. Year: 2025 Issue: Volume: Abstract: This book is the first comprehensive edited volume focused on treatment approaches for chronic pain specifically in women and girls. Utilizing evidence-based psychosocial techniques, it is directly applicable to the work of all mental health practitioners, and provides a rich resource of descriptions of chronic pain conditions that predominantly or uniquely impact women and girls, as well as practical guidance for implementing treatment, enriched by detailed case studies. Since chronic pain in women and girls is often minimized or dismissed in the medical setting, this book provides new insights into the understanding and management of chronic pain specifically in the female population. (PsycInfo Database Record (c) 2026 APA, all rights reserved)