Médecine transfusionnelle

Abstract Background Restrictive transfusion strategies and patient blood management programs increasingly recommend administration of single-unit red blood cell (RBC) transfusions followed by reassessment. However, clinicians often lack objective indicators to determine whether additional transfusion may subsequently be administered after the…

J Int Med Res. 2026 Jun;54(6):3000605261452582. doi: 10.1177/03000605261452582. Epub 2026 Jun 6. ABSTRACT This case study examines a 22-year-old unmarried woman who experienced shock resulting from rupture of a corpus luteum cyst. During the perioperative period, the patient received multiple transfusions of red blood cells and fresh frozen plasma…

Eur J Neurol. 2026 Jul;33(7):e70698. doi: 10.1111/ene.70698. ABSTRACT BACKGROUND: Irradiation of cellular blood components prevents transfusion-associated graft-versus-host disease (TA-GVHD). UK and Spanish guidance recommend lifelong irradiation for all patients treated with purine analogues, including cladribine, irrespective of indication or…

Lab Med. 2026 Apr 3;57(3):lmag031. doi: 10.1093/labmed/lmag031. ABSTRACT INTRODUCTION: Transfusion-transmitted cytomegalovirus remains a clinically significant risk in immunocompromised individuals, neonates, and transplant recipients. Despite widespread universal leukoreduction and pathogen-reduction technologies, uncertainty persists regarding…

Br J Haematol. 2026 Mar;208(3):1074-1083. doi: 10.1111/bjh.70371. Epub 2026 Feb 18. ABSTRACT Few studies have compared the prevalence of transfusion reactions (TRs) in paediatric and adult recipients, and none have been conducted in Canada. We carried out a retrospective cross-sectional study of TRs reported in a Canadian haemovigilance system (i…

Transpl Immunol. 2026 Apr;95:102365. doi: 10.1016/j.trim.2026.102365. Epub 2026 Feb 23. ABSTRACT Despite significant advances in immunosuppression strategies, antibody-mediated rejection (AMR) remains a leading cause of graft dysfunction and loss after heart transplantation. Donor-specific anti-HLA antibodies (DSA), either preformed or de novo,…

PLoS One. 2026 Apr 6;21(4):e0346680. doi: 10.1371/journal.pone.0346680. eCollection 2026. ABSTRACT INTRODUCTION: Transfusion is a critical life-saving intervention, but the safety of the blood supply remains a major public health concern, particularly in sub-Saharan Africa, due to the risk of transfusion-transmitted infections (TTIs). This study…

New Microbiol. 2026 Apr;49(1):11-17. ABSTRACT Transfusion of stored red blood cells (RBCs) is a life-saving intervention in trauma, surgery, and critical care. However, storage-induced alterations, collectively termed "storage lesions," lead to the accumulation of bioactive mediators, including mitochondrial DNA (mtDNA), which functions as a…

Ann Card Anaesth. 2026 Apr 1;29(2):204-211. doi: 10.4103/aca.aca_208_25. Epub 2026 Apr 15. ABSTRACT OBJECTIVES: Blood transfusion is an integral part of pediatric cardiac surgery. Our study intends to analyze the incidence of transfusion reactions in pediatric cardiac surgery patients. Secondary objectives were to identify the common type of…

Transplant Direct. 2026 Jul 2;12(8):e1972. doi: 10.1097/TXD.0000000000001972. eCollection 2026 Aug. ABSTRACT BACKGROUND: Simultaneous pancreas-kidney transplantation (SPK) is the optimal treatment for selected patients with type I diabetes mellitus (T1DM) and end-stage kidney disease, but intraoperative bleeding remains a major cause of morbidity…

Diagn Pathol. 2026 Jul 7. doi: 10.1186/s13000-026-01797-5. Online ahead of print. ABSTRACT BACKGROUND: Thalidomide has been found to augment fetal hemoglobin (HbF) synthesis, thereby decreasing transfusion requirements in patients with β-thalassemia. Elevated fetal hemoglobin, influenced by genetic polymorphisms, can significantly modify the…

ACS Omega. 2026 May 13;11(20):29683-29690. doi: 10.1021/acsomega.5c13313. eCollection 2026 May 26. ABSTRACT Leukocytes need to be eliminated from blood components in order to lower the risk of adverse transfusion responses and guarantee patient safety during transfusion. Nowadays, nonwoven fabric filters are typically used to remove leukocytes…

Transfusion. 2026 Apr 13. doi: 10.1111/trf.70194. Online ahead of print. ABSTRACT BACKGROUND: Anaplasma phagocytophilum is a tick-borne pathogen that causes anaplasmosis. Increased incidences of this disease in Canada and cases of transfusion-transmitted anaplasmosis in the United States have been reported. Currently, there are no Health Canada…

Abstract Background The contraction of blood clots is a dramatic platelet-dependent process that minimizes the impact of thrombosis and supports the closure of lacerations. Whole blood (WB) stored up to 35 days is increasingly used to treat hemorrhagic shock, but the clot contractibility of this stored blood is unknown. We hypothesized that clot…

Transfusion. 2026 Jun 22. doi: 10.1111/trf.70316. Online ahead of print. ABSTRACT BACKGROUND: It is imperative that health systems monitor transfusion practice quality and implement improvements when evidence-based practice gaps are identified. Despite the importance of data-driven quality activities, little is known about approaches employed by…

Vox Sang. 2026 May 15. doi: 10.1111/vox.70267. Online ahead of print. ABSTRACT BACKGROUND AND OBJECTIVES: Patient blood management (PBM) as a standard-of-care approach, sustained by substantial scientific literature, is now widely supported by national and international recommendations and guidelines. Scientific evidence shows that PBM is a…

PLoS One. 2026 Mar 25;21(3):e0344521. doi: 10.1371/journal.pone.0344521. eCollection 2026. ABSTRACT INTRODUCTION: Due to the absence of prior institutional assessments and limited local studies lacking key performance indicators, this study examines the operational efficiency of the blood bank at King Fahad Medical City (KFMC) in Riyadh, Saudi…

Abstract Background and Objectives The global blood product shortage is a persistent problem that urgently needs addressing. Research has investigated the effects of incentives, different interventions and different modes of communication on promoting blood donation; yet, there has been no systematic review comparing interactive communication…

Abstract Background Substituting group A whole blood (GAWB) might relieve some of the burden on the low titer group O whole blood (LTOWB) inventory. This simulation examined the effect of implementing GAWB at a large trauma hospital. Study Design and Methods A civilian trauma center with LTOWB and GAWB par levels set to 22 and 10 units,…

Immunohematology. 2026 Apr 10;42(1):6-13. doi: 10.2478/immunohematology-2026-003. Print 2026 Mar 1. ABSTRACT The Japanese Red Cross Blood Services archives donor blood samples from all donations for look-back surveys. These samples, approximately 5 million per year, are stored frozen at -30°C for 11 years and are subsequently discarded. Because…

Ann Hematol. 2026 Apr 16;105(5):248. doi: 10.1007/s00277-026-06992-4. ABSTRACT High-frequency plateletpheresis is crucial for meeting transfusion demands but poses a significant risk of cumulative iron depletion in donors. Current screening protocols relying solely on hemoglobin (Hb) fail to detect latent iron deficiency (LID), a condition where…

Blood Adv. 2026 Jul 8:bloodadvances.2026019856. doi: 10.1182/bloodadvances.2026019856. Online ahead of print. ABSTRACT Gene therapy for sickle cell disease and transfusion-dependent thalassemia is now widely available, yet its broader application is constrained by the need for effective and tolerable conditioning. This review examines the central…

Health Sci Rep. 2026 Jul 7;9(7):e72778. doi: 10.1002/hsr2.72778. eCollection 2026 Jul. ABSTRACT BACKGROUND: It is common to perform a splenectomy for patients with sickle cell disease (SCD); however, our understanding of its impact on long-term clinical outcomes remains incomplete. OBJECTIVES: To evaluate the clinical outcomes of splenectomy in…

Hip Pelvis. 2026 Jun 1;38(2):187-195. doi: 10.5371/hp.2026.38.2.187. ABSTRACT PURPOSE: There is ongoing debate on the haemoglobin level at which red cell transfusion should be administered following surgery. This study aimed to evaluate the benefits of a restrictive blood transfusion strategy and assess potential adverse effects of anaemia in the…

Blood. 2026 Jun 2:blood.2025032290. doi: 10.1182/blood.2025032290. Online ahead of print. ABSTRACT Non-myeloablative-related haploidentical allogeneic stem cell transplantation (NMAC-HID allo-HSCT) emerged as an additional treatment for achieving durable remission in SCD, a prevalent blood disorder characterized by painful vaso-occlusive crises…

Biomaterials. 2026 May 28;335:124345. doi: 10.1016/j.biomaterials.2026.124345. Online ahead of print. ABSTRACT Red blood cell (RBC) transfusion is a cornerstone of life-sustaining therapy, yet it is profoundly challenged in autoimmune hemolytic anemia (AIHA). In this disorder, a diverse array of autoantibodies targets both the autologous and…

Abstract Background Many blood centers now accept donors with diabetes, provided their condition is “well-controlled”. However, glycemic control is not routinely assessed at donation, and the impact of donor diabetes on blood product quality remains unclear. Study Design and Methods To screen glycemic control, glycated hemoglobin A1c (HbA1c) was…

J Hematol. 2026 Apr 6;15(2):80-89. doi: 10.14740/jh2178. eCollection 2026 Apr. ABSTRACT BACKGROUND: In the intensive care unit (ICU), up to 90% of patients develop anemia during their stay. However, evidence regarding transfusion practices in oncology patients requiring ICU-level care is limited. This study aimed to compare mortality, survival…

Medicine (Baltimore). 2026 Apr 10;105(15):e48140. doi: 10.1097/MD.0000000000048140. ABSTRACT In Japan, preoperative autologous blood donation (ABD) is widely performed in orthognathic surgery to avoid allogeneic transfusion. Although previous studies have examined postoperative hemoglobin (Hb) fluctuations and the safety of autologous blood…

J Int Med Res. 2026 Jul;54(7):3000605261463827. doi: 10.1177/03000605261463827. Epub 2026 Jul 6. ABSTRACT ObjectiveTo evaluate the association between a prehospital-to-in-hospital integrated transfusion workflow and transfusion timeliness, coagulation-related indices, and short-term clinical outcomes in patients with severe trauma requiring…

JAMA Surg. 2026 Jul 8. doi: 10.1001/jamasurg.2026.2574. Online ahead of print. ABSTRACT IMPORTANCE: Hemorrhage remains the leading preventable cause of trauma death, and many fatalities occur before definitive hemorrhage control. Whole blood has reemerged as a promising strategy for early hemostatic resuscitation. However, its modern role remains…

Eur J Haematol. 2026 May 31. doi: 10.1111/ejh.70233. Online ahead of print. ABSTRACT BACKGROUND: Real-world data on transfusion needs of patients with myelodysplastic syndromes (MDS), and the impacts of disease-modifying therapies (DMTs) are sparse. In 2011, 5-azacitidine became the first funded DMT for MDS and chronic myelomonocytic leukaemia …

J Clin Lab Anal. 2026 Jun 2:e70272. doi: 10.1002/jcla.70272. Online ahead of print. ABSTRACT BACKGROUND: Beta-thalassemia is a genetically heterogeneous hemoglobinopathy with marked clinical variability. In Spain, comprehensive nationwide data on transfusion-dependent beta-thalassemia (TDT) remain limited, particularly regarding molecular…

Abstract Background Anaplasma phagocytophilum is a tick-borne pathogen that causes anaplasmosis. Increased incidences of this disease in Canada and cases of transfusion-transmitted anaplasmosis in the United States have been reported. Currently, there are no Health Canada licensed methodologies available for detection of A. phagocytophilum nucleic…