Phénotypage de rongeurs – métabolique

La plateforme de phénotypage de rongeurs – métabolique du CRCHUM a contribué à la publication des articles scientifiques suivants : 
 

1. ^{Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid–Induced Rat β-Cell Proliferation. Alexis Vivoli, Julien Ghislain, Ali Filali-Mouhim, Zuraya Elisa Angeles, Anne-Laure Castell, Robert Sladek, Vincent Poitout, Diabetes 2023 Jan 1}
2. ^{β Cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood. Anne-Laure Castell, Clara Goubault, Mélanie Ethier, Grace Fergusson, Caroline Tremblay, Marie Baltz, Dorothée Dal Soglio, Julien Ghislain, Vincent Poitout, JCI Insight. 2022 Nov 8}
3. ^{Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis. Abdelnabi MN, Flores Molina M, Soucy G, Quoc-Huy Trinh V, Bédard N, Mazouz S, Jouvet N, Dion J, Tran S, Bilodeau M, Estall JL, Shoukry NH. Cell Mol Gastroenterol Hepatol. 2022 Aug 13}
4. ^{Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic β-cells that controls insulin secretion and metabolic stress. Al-Mass A, Poursharifi P, Peyot ML, Lussier R, Levens EJ, Guida J, Mugabo Y, Possik E, Ahmad R, Al-Mulla F, Sladek R, Madiraju SRM, Prentki M. Mol Metab. 2022 Jun}
5. ^{Role of astroglial ACBP in energy metabolism flexibility and feeding responses to metabolic challenges in male mice. Bouyakdan K, Manceau R, Robb JL, Rodaros D, Fulton S, Alquier T. J Neuroendocrinol. 2022 Dec}
6. ^{Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control liver metabolism and glucodetoxification under hyperglycemia. Al-Mass A, Poursharifi P, Peyot ML, Lussier R, Chenier I, Leung YH, Ghosh A, Oppong A, Possik E, Mugabo Y, Ahmad R, Sladek R, Murthy Madiraju SR, Al-Mulla F, Prentki M. Mol Metab. 2022 Dec}
7. ^{Temporal dissection of Rai1 function reveals brain-derived neurotrophic factor as a potential therapeutic target for Smith-Magenis syndrome. Javed S, Lee YJ, Xu J, Huang WH. Hum Mol Genet. 2021 Dec 27}
8. ^{Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity. Diaz-Marin R, Crespo-Garcia S, Wilson AM, Buscarlet M, Dejda A, Fournier F, Juneau R, Alquier T, Sapieha P. Sci Rep. 2021 Aug 3}
9. ^{Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice. Marine L Croze, Marcus F Flisher, Arthur Guillaume, Caroline Tremblay, Glyn M Noguchi, Sabrina Granziera, Kevin Vivot, Vincent C Castillo, Scott A Campbell, Julien Ghislain, Mark O Huising, Vincent Poitout. Mol Metab. 2021 Mar}
10. ^{Adipose ABHD6 regulates tolerance to cold and thermogenic programs. Poursharifi P, Attané C, Mugabo Y, Al-Mass A, Ghosh A, Schmitt C, Zhao S, Guida J, Lussier R, Erb H, Chenier I, Peyot ML, Joly E, Noll C, Carpentier AC, Madiraju SRM, Prentki M. JCI Insight. 2020 Dec 17}
11. ^{14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance. Diallo K, Dussault S, Noll C, Lopez AF, Rivard A, Carpentier AC, Lim GE. Mol Metab. 2020 Nov}
12. ^{HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats. Maachi H, Fergusson G, Ethier M, Brill GN, Katz LS, Honig LB, Metukuri MR, Scott DK, Ghislain J, Poitout V. Diabetes. 2020 Mar}
13. ^{The autonomic nervous system regulates pancreatic β-cell proliferation in adult male rats. Valentine S. Moullé, Caroline Tremblay, Anne-Laure Castell, Kevin Vivot, Mélanie Ethier, Grace Fergusson, Thierry Alquier, Julien Ghislain, and Vincent Poitout, Am J Physiol Endocrinol Metab. 2019 Aug 1}
14. ^{The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system. Bouyakdan K, Martin H, Liénard F, Budry L, Taib B, Rodaros D, Chrétien C, Biron É, Husson Z, Cota D, Pénicaud L, Fulton S, Fioramonti X, Alquier T. J Clin Invest. 2019 Apr 2}
15. ^{Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat. Décarie-Spain L, Sharma S, Hryhorczuk C, Issa-Garcia V, Barker PA, Arbour N, Alquier T, Fulton S. Mol Metab. 2018 Apr}
16. ^{Considerations and guidelines for mouse metabolic phenotyping in diabetes research. Alquier T, Poitout V. Diabetologia. 2018 Mar}
17. ^{Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice. Bergeron V, Ghislain J, Vivot K, Tamarina N, Philipson LH, Fielitz J, Poitout V. Diabetes. 2018 Jan}
18. ^{Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats. Moullé VS, Vivot K, Tremblay C, Zarrouki B, Ghislain J, Poitout V. Diabetologia. 2017 May}
19. ^{α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes. Zhao S, Mugabo Y, Ballentine G, Attane C, Iglesias J, Poursharifi P, Zhang D, Nguyen TA, Erb H, Prentki R, Peyot ML, Joly E, Tobin S, Fulton S, Brown JM, Madiraju SR, Prentki M. Cell Rep. 2016 Mar 29}
20. ^{Dual-Reporter β-Cell-Specific Male Transgenic Rats for the Analysis of β-Cell Functional Mass and Enrichment by Flow Cytometry. Ghislain J, Fontés G, Tremblay C, Kebede MA, Poitout V. Endocrinology. 2016 Mar}
21. ^{The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated with Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice. Fontés G, Ghislain J, Benterki I, Zarrouki B, Trudel D, Berthiaume Y, Poitout V. Diabetes. 2015 Dec}
22. ^{PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids. Oropeza D, Jouvet N, Bouyakdan K, Perron G, Ringuette LJ, Philipson LH, Kiss RS, Poitout V, Alquier T, Estall JL. Mol Metab. 2015 Aug 14}
23. ^{Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice. Fergusson G, Ethier M, Guévremont M, Chrétien C, Attané C, Joly E, Fioramonti X, Prentki M, Poitout V, Alquier T. Mol Metab. 2014 Sep 28}
24. ^{Epidermal growth factor receptor signaling promotes pancreatic β-cell proliferation in response to nutrient excess in rats through mTOR and FOXM1. Zarrouki B, Benterki I, Fontés G, Peyot ML, Seda O, Prentki M, Poitout V. Diabetes. 2014 Mar}
25. ^{A model of chronic nutrient infusion in the rat. Fergusson G, Ethier M, Zarrouki B, Fontés G, Poitout V. J Vis Exp. 2013 Aug 14}
26. ^{Pioglitazone acutely reduces energy metabolism and insulin secretion in rats. Lamontagne J, Jalbert-Arsenault E, Pepin E, Peyot ML, Ruderman NB, Nolan CJ, Joly E, Madiraju SR, Poitout V, Prentki M. Diabetes. 2013 Jun}
27. ^{G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1. Ferdaoussi M, Bergeron V, Zarrouki B, Kolic J, Cantley J, Fielitz J, Olson EN, Prentki M, Biden T, MacDonald PE, Poitout V. Diabetologia. 2012}
28. ^{Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling. Amyot J, Semache M, Ferdaoussi M, Fontés G, Poitout V. PLoS One. 2012}
29. ^{Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression. Amyot J, Benterki I, Fontés G, Hagman DK, Ferdaoussi M, Teodoro T, Volchuk A, Joly É, Poitout V. J Mol Endocrinol. 2011 Sep 30}
30. ^{Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity. Fontés G, Hagman DK, Latour MG, Semache M, Poitout V. Diabetes Res Clin Pract. 2010 Mar}