Phénotypage et imagerie petits animaux

^{Single-Cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty Acid–Induced Rat β-Cell Proliferation. Alexis Vivoli, Julien Ghislain, Ali Filali-Mouhim, Zuraya Elisa Angeles, Anne-Laure Castell, Robert Sladek, Vincent Poitout, Diabetes 2023 Jan 1}

^{β Cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood. Anne-Laure Castell, Clara Goubault, Mélanie Ethier, Grace Fergusson, Caroline Tremblay, Marie Baltz, Dorothée Dal Soglio, Julien Ghislain, Vincent Poitout, JCI Insight. 2022 Nov 8}

^{Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis. Abdelnabi MN, Flores Molina M, Soucy G, Quoc-Huy Trinh V, Bédard N, Mazouz S, Jouvet N, Dion J, Tran S, Bilodeau M, Estall JL, Shoukry NH. Cell Mol Gastroenterol Hepatol. 2022 Aug 13}

^{Glycerol-3-phosphate phosphatase operates a glycerol shunt in pancreatic β-cells that controls insulin secretion and metabolic stress. Al-Mass A, Poursharifi P, Peyot ML, Lussier R, Levens EJ, Guida J, Mugabo Y, Possik E, Ahmad R, Al-Mulla F, Sladek R, Madiraju SRM, Prentki M. Mol Metab. 2022 Jun}

^{Role of astroglial ACBP in energy metabolism flexibility and feeding responses to metabolic challenges in male mice. Bouyakdan K, Manceau R, Robb JL, Rodaros D, Fulton S, Alquier T. J Neuroendocrinol. 2022 Dec}

^{Hepatic glycerol shunt and glycerol-3-phosphate phosphatase control liver metabolism and glucodetoxification under hyperglycemia. Al-Mass A, Poursharifi P, Peyot ML, Lussier R, Chenier I, Leung YH, Ghosh A, Oppong A, Possik E, Mugabo Y, Ahmad R, Sladek R, Murthy Madiraju SR, Al-Mulla F, Prentki M. Mol Metab. 2022 Dec}

^{Temporal dissection of Rai1 function reveals brain-derived neurotrophic factor as a potential therapeutic target for Smith-Magenis syndrome. Javed S, Lee YJ, Xu J, Huang WH. Hum Mol Genet. 2021 Dec 27}

^{Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity. Diaz-Marin R, Crespo-Garcia S, Wilson AM, Buscarlet M, Dejda A, Fournier F, Juneau R, Alquier T, Sapieha P. Sci Rep. 2021 Aug 3}

^{Free fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice. Marine L Croze, Marcus F Flisher, Arthur Guillaume, Caroline Tremblay, Glyn M Noguchi, Sabrina Granziera, Kevin Vivot, Vincent C Castillo, Scott A Campbell, Julien Ghislain, Mark O Huising, Vincent Poitout. Mol Metab. 2021 Mar}

^{Adipose ABHD6 regulates tolerance to cold and thermogenic programs. Poursharifi P, Attané C, Mugabo Y, Al-Mass A, Ghosh A, Schmitt C, Zhao S, Guida J, Lussier R, Erb H, Chenier I, Peyot ML, Joly E, Noll C, Carpentier AC, Madiraju SRM, Prentki M. JCI Insight. 2020 Dec 17}

^{14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance. Diallo K, Dussault S, Noll C, Lopez AF, Rivard A, Carpentier AC, Lim GE. Mol Metab. 2020 Nov}

^{HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats. Maachi H, Fergusson G, Ethier M, Brill GN, Katz LS, Honig LB, Metukuri MR, Scott DK, Ghislain J, Poitout V. Diabetes. 2020 Mar}

^{The autonomic nervous system regulates pancreatic β-cell proliferation in adult male rats. Valentine S. Moullé, Caroline Tremblay, Anne-Laure Castell, Kevin Vivot, Mélanie Ethier, Grace Fergusson, Thierry Alquier, Julien Ghislain, and Vincent Poitout, Am J Physiol Endocrinol Metab. 2019 Aug 1}

^{The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system. Bouyakdan K, Martin H, Liénard F, Budry L, Taib B, Rodaros D, Chrétien C, Biron É, Husson Z, Cota D, Pénicaud L, Fulton S, Fioramonti X, Alquier T. J Clin Invest. 2019 Apr 2}

^{Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat. Décarie-Spain L, Sharma S, Hryhorczuk C, Issa-Garcia V, Barker PA, Arbour N, Alquier T, Fulton S. Mol Metab. 2018 Apr}

^{Considerations and guidelines for mouse metabolic phenotyping in diabetes research. Alquier T, Poitout V. Diabetologia. 2018 Mar}

^{Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice. Bergeron V, Ghislain J, Vivot K, Tamarina N, Philipson LH, Fielitz J, Poitout V. Diabetes. 2018 Jan}

^{Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats. Moullé VS, Vivot K, Tremblay C, Zarrouki B, Ghislain J, Poitout V. Diabetologia. 2017 May}

^{α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes. Zhao S, Mugabo Y, Ballentine G, Attane C, Iglesias J, Poursharifi P, Zhang D, Nguyen TA, Erb H, Prentki R, Peyot ML, Joly E, Tobin S, Fulton S, Brown JM, Madiraju SR, Prentki M. Cell Rep. 2016 Mar 29}

^{Dual-Reporter β-Cell-Specific Male Transgenic Rats for the Analysis of β-Cell Functional Mass and Enrichment by Flow Cytometry. Ghislain J, Fontés G, Tremblay C, Kebede MA, Poitout V. Endocrinology. 2016 Mar}

^{The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated with Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice. Fontés G, Ghislain J, Benterki I, Zarrouki B, Trudel D, Berthiaume Y, Poitout V. Diabetes. 2015 Dec}

^{PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids. Oropeza D, Jouvet N, Bouyakdan K, Perron G, Ringuette LJ, Philipson LH, Kiss RS, Poitout V, Alquier T, Estall JL. Mol Metab. 2015 Aug 14}

^{Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice. Fergusson G, Ethier M, Guévremont M, Chrétien C, Attané C, Joly E, Fioramonti X, Prentki M, Poitout V, Alquier T. Mol Metab. 2014 Sep 28}

^{Epidermal growth factor receptor signaling promotes pancreatic β-cell proliferation in response to nutrient excess in rats through mTOR and FOXM1. Zarrouki B, Benterki I, Fontés G, Peyot ML, Seda O, Prentki M, Poitout V. Diabetes. 2014 Mar}

^{A model of chronic nutrient infusion in the rat. Fergusson G, Ethier M, Zarrouki B, Fontés G, Poitout V. J Vis Exp. 2013 Aug 14}

^{Pioglitazone acutely reduces energy metabolism and insulin secretion in rats. Lamontagne J, Jalbert-Arsenault E, Pepin E, Peyot ML, Ruderman NB, Nolan CJ, Joly E, Madiraju SR, Poitout V, Prentki M. Diabetes. 2013 Jun}

^{G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1. Ferdaoussi M, Bergeron V, Zarrouki B, Kolic J, Cantley J, Fielitz J, Olson EN, Prentki M, Biden T, MacDonald PE, Poitout V. Diabetologia. 2012}

^{Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling. Amyot J, Semache M, Ferdaoussi M, Fontés G, Poitout V. PLoS One. 2012}

^{Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression. Amyot J, Benterki I, Fontés G, Hagman DK, Ferdaoussi M, Teodoro T, Volchuk A, Joly É, Poitout V. J Mol Endocrinol. 2011 Sep 30}

^{Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity. Fontés G, Hagman DK, Latour MG, Semache M, Poitout V. Diabetes Res Clin Pract. 2010 Mar}

^{Deng AY, Menard A, Deng DW. Shifting Paradigm from Gene Expressions to Pathways Reveals Physiological Mechanisms in Blood Pressure Control in Causation. Int J Mol Sci. 2023 Jan 9; 24(2):1262. doi: 10.3390/ijms24021262. (Telemetry)}

^{Bouyakdan K, Manceau R, Robb JL, Rodaros D, Fulton S, Alquier T. Role of astroglial ACBP in energy metabolism flexibility and feeding responses to metabolic challenges in male mice. J Neuroendocrinol. 2022 Dec; 34(12):e13218. (EchoMRI)}

^{Claire Gerkins, Roy Hajjar, Manon Oliero, Manuela M Santos. Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran. J Vis Exp. 2022 Nov 18;(189). (Optix-MX2)}

^{Mohamed N Abdelnabi , Manuel Flores Molina , Geneviève Soucy , Vincent Quoc-Huy Trinh , Nathalie Bédard , Sabrina Mazouz , Nathalie Jouvet , Jessica Dion , Sarah Tran , Marc Bilodeau , Jennifer L Estall , Naglaa H Shoukry Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis. Cell Mol Gastroenterol Hepatol. 2022; 14(6):1269-1294. Epub 2022 Aug 13. (EchoMRI)}

^{Lan S, Yang B, Migneault F, Turgeon J, Bourgault M, Dieudé M, Cardinal H, Hickey MJ, Patey N, Hébert MJ. Caspase-3-dependent peritubular capillary dysfunction is pivotal for the transition from acute to chronic kidney disease after acute ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2021 Sep 1; 321(3):F335-F351. (skyscan1176)}

^{Touani FK, Borie M, Azzi F, Trudel D, Noiseux N, Der Sarkissian S, Lerouge S. Pharmacological Preconditioning Improves the Viability and Proangiogenic Paracrine Function of Hydrogel-Encapsulated Mesenchymal Stromal Cells. Stem Cells Int. 2021 Jul 28; 2021:6663467. (Optix-MX2)}

^{Roberto Diaz-Marin, Sergio Crespo-Garcia, Ariel M Wilson, Manuel Buscarlet, Agnieszka Dejda, Frédérik Fournier, Rachel Juneau, Thierry Alquier, Przemyslaw Sapieha. Myeloid-resident neuropilin-1 influences brown adipose tissue in obesity. Sci Rep. 2021 Aug 3;11(1):15767. (EchoMRI)}

^{Grygorczyk R, Boudreault F, Ponomarchuk O, Tan JJ, Furuya K, Goldgewicht J, Kenfack FD, Yu F. Lytic Release of Cellular ATP: Physiological Relevance and Therapeutic Applications. Life (Basel). 2021 Jul 16; 11(7):700. (Optix-MX2)}

<sup>Croze ML, Guillaume A, Ethier M, Fergusson G, Tremblay C, Campbell SA, Maachi H, Ghislain J, Poitout V.

Combined Deletion of Free Fatty-Acid Receptors 1 and 4 Minimally Impacts Glucose Homeostasis in Mice. Endocrinology. 2021 Mar 1; 162(3):bqab002. (EchoMRI)</sup>

^{Ouhaddi Y, Najar M, Paré F, Lussier B, Urade Y, Benderdour M, Pelletier JP, Martel-Pelletier J, Fahmi H. L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis. Aging (Albany NY). 2020 Dec 23;12(24):24778-24797. (skyscan1176)}

^{Diallo K, Dussault S, Noll C, Lopez AF, Rivard A, Carpentier AC, Lim GE. 14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance. Mol Metab. 2020 Nov; 41:101052. (EchoMRI)}

^{Amate M, Goldgewicht J, Sellamuthu B, Stagg J, Yu FTH. The effect of ultrasound pulse length on microbubble cavitation induced antibody accumulation and distribution in a mouse model of breast cancer. Nanotheranostics. 2020 Sep 15; 4(4):256-269. (Optix-MX2)}

^{Najar M, Ouhaddi Y, Paré F, Lussier B, Urade Y, Kapoor M, Pelletier JP, Martel-Pelletier J, Benderdour M, Fahmi H. Arthritis Rheumatol. Role of Lipocalin-Type Prostaglandin D Synthase in Experimental Osteoarthritis. 2020 Sep; 72(9):1524-1533. (skyscan1176)}

^{Deng AY, Ménard A. Conserved mammalian modularity of quantitative trait loci revealed human functional orthologs in blood pressure control. PLoS One. 2020 Jul 23; 15(7):e0235756. (Telemetry)}

^{Deng AY. Modularity/non-cumulativity of quantitative trait loci on blood pressure. J Hum Hypertens. 2020 Jun; 34(6):432-439. (Telemetry)}

^{Deng AY, Ménard A. Functional Captures of Multiple Human Quantitative Trait Loci Regulating Blood Pressure with the Use of Orthologs in Genetically Defined Rat Models.  Can J Cardiol. 2020 May; 36(5):756-763. (Telemetry)}

^{Deng AY, Ménard A. Biological convergence of three human and animal model quantitative trait loci for blood pressure. J Hypertens. 2020 Feb; 38(2):322-331. (Telemetry)}

^{Paré F, Tardif G, Fahmi H, Ouhaddi Y, Pelletier JP, Martel-Pelletier J. In vivo protective effect of adipsin-deficiency on spontaneous knee osteoarthritis in aging mice. Aging (Albany NY). 2020 Feb 1; 12(3):2880-2896. (skyscan1176)}

^{Deng AY, Huot-Marchard JÉ, deBlois D, Thorin E, Chauvet C, Menard A. Functional Dosage of Muscarinic Cholinergic Receptor 3 Signalling, Not the Gene Dose, Determines Its Hypertension Pathogenesis. Can J Cardiol. 2019 May; 35(5):661-670. (Telemetry)}

^{Bouyakdan K, Martin H, Liénard F, Budry L, Taib B, Rodaros D, Chrétien C, Biron É, Husson Z, Cota D, Pénicaud L, Fulton S, Fioramonti X, Alquier T. The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system. J Clin Invest. 2019 Apr 2; 129(6):2417-2430. (EchoMRI)}

^{Deng AY, deBlois D, Laporte SA, Gelinas D, Tardif JC, Thorin E, Shi Y, Raignault A, Ménard A. Novel Pathogenesis of Hypertension and Diastolic Dysfunction Caused by M3R (Muscarinic Cholinergic 3 Receptor) Signaling. Hypertension. 2018 Sep; 72(3):755-764. (Telemetry)}

^{Léa Décarie-Spain, Sandeep Sharma, Cécile Hryhorczuk, Victor Issa-Garcia, Philip A Barker, Nathalie Arbour , Thierry Alquier , Stephanie Fulton Nucleus accumbens inflammation mediates anxiodepressive behavior and compulsive sucrose seeking elicited by saturated dietary fat. Mol Metab. 2018 Apr; 10:1-13. (EchoMRI)}

^{Bergeron V, Ghislain J, Vivot K, Tamarina N, Philipson LH, Fielitz J, Poitout V. Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice. Diabetes. 2018 Jan; 67(1):71-77. (EchoMRI)}

^{Ouhaddi Y, Nebbaki SS, Habouri L, Afif H, Lussier B, Kapoor M, Narumiya S, Pelletier JP, Martel-Pelletier J, Benderdour M, Fahmi H. Exacerbation of Aging-Associated and Instability-Induced Murine Osteoarthritis With Deletion of D Prostanoid Receptor 1, a Prostaglandin D₂ Receptor. Arthritis Rheumatol. 2017 Sep; 69(9):1784-1795. (skyscan1176)}

^{Bosoi CR, Oliveira MM, Ochoa-Sanchez R, Tremblay M, Ten Have GA, Deutz NE, Rose CF, Bemeur C. The bile duct ligated rat: A relevant model to study muscle mass loss in cirrhosis. Metab Brain Dis. 2017 Apr; 32(2):513-518. (EchoMRI)}

^{Yang B, Dieudé M, Hamelin K, Hénault-Rondeau M, Patey N, Turgeon J, Lan S, Pomerleau L, Quesnel M, Peng J, Tremblay J, Shi Y, Chan JS, Hébert MJ, Cardinal H. Anti-LG3 Antibodies Aggravate Renal Ischemia-Reperfusion Injury and Long-Term Renal Allograft Dysfunction. Am J Transplant. 2016 Dec; 16(12):3416-3429. (Renal IR model)}

^{Wang Y, Hamet P, Thorin E, Tremblay J, Raelson J, Wu Z, Luo H, Jin W, Lavoie JL, Peng J, Marois-Blanchet FC, Tahir MR, Chalmers J, Woodward M, Harrap S, Qi S, Li CY, Wu J. Reduced blood pressure after smooth muscle EFNB2 deletion and the potential association of EFNB2 mutation with human hypertension risk. Eur J Hum Genet. 2016 Dec; 24(12):1817-1825. (Telemetry)}

^{Wang Y, Wu Z, Luo H, Peng J, Raelson J, Ehret GB, Munroe PB, Stoyanova E, Qin Z, Cloutier G, Bradley WE, Wu T, Shen JZ, Hu S, Wu J. The role of GRIP1 and ephrin B3 in blood pressure control and vascular smooth muscle cell contractility. Sci Rep. 2016 Dec 12; 6:38976. (Telemetry)}

^{Shamansurova Z, Tan P, Ahmed B, Pepin E, Seda O, Lavoie JL. Adipose tissue (P)RR regulates insulin sensitivity, fat mass and body weight. Mol Metab. 2016 Aug 23;5(10):959-969. (EchoMRI)}

^{Crespo K, Ménard A, Deng AY. Retinoblastoma-associated protein 140 as a candidate for a novel etiological gene to hypertension. Clin Exp Hypertens. 2016; 38(6):533-40. doi: 10.3109/10641963.2016.1163373. Epub 2016 Jul 8. (Telemetry)}

^{Wang Y, Wu Z, Thorin E, Tremblay J, Lavoie JL, Luo H, Peng J, Qi S, Wu T, Chen F, Shen J, Hu S, Wu J. Estrogen and testosterone in concert with EFNB3 regulate vascular smooth muscle cell contractility and blood pressure. Am J Physiol Heart Circ Physiol. 2016 Apr 1; 310(7):H861-72. (Telemetry)}

^{Deng AY, Chauvet C, Ménard A. Alterations in Fibronectin Type III Domain Containing 1 Protein Gene Are Associated with Hypertension. PLoS One. 2016 Apr 11; 11(4):e0151399. (Telemetry)} 

^{Zhao S, Mugabo Y, Ballentine G, Attane C, Iglesias J, Poursharifi P, Zhang D, Nguyen TA, Erb H, Prentki R, Peyot ML, Joly E, Tobin S, Fulton S, Brown JM, Madiraju SR, Prentki M. α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes. Cell Rep. 2016 Mar 29;14(12):2872-88. (EchoMRI)}

^{Ghislain J, Fontés G, Tremblay C, Kebede MA, Poitout V. Dual-Reporter β-Cell-Specific Male Transgenic Rats for the Analysis of β-Cell Functional Mass and Enrichment by Flow Cytometry. Endocrinology. 2016 Mar;157(3):1299-306. (EchoMRI)}

^{Chauvet C, Ménard A, Deng AY. Two candidate genes for two quantitative trait loci epistatically attenuate hypertension in a novel pathway. J Hypertens. 2015 Sep; 33(9):1791-801; discussion 1801. (Telemetry)} 

^{Plante E, Menaouar A, Danalache BA, Yip D, Broderick TL, Chiasson JL, Jankowski M, Gutkowska J. Oxytocin treatment prevents the cardiomyopathy observed in obese diabetic male db/db mice. Endocrinology. 2015 Apr; 156(4):1416-28. (Vevo 770)}