Les études réalisées grâce à la contribution de la plateforme de pharmacocinétique du CRCHUM sont au cœur de plusieurs publications avec comité de lecture. 

1. Frouni I., Bédard D., Bourgeois-Cayer É., Hamadjida A., Gaudette F., Beaudry F., Huot P. Pharmacokinetic profile of bitopertin, a selective GlyT1 inhibitor, in the rat. Naunym Schmiedebergs Arch Pharmacol. (2023) PMID: 36633618.

2. Burjorjee J., Phelan R., Hopman WM., Ho A. M-H., Nanji S., Jalink D. and Mizubuti GB. Plasma bupivacaine level (total and free/unbound) during epidural infusion in liver resection patients: a prospective, observational study. Reg Anesth Pain Med (2022) PMID: 36002226.

3. Garbin M., Benitio J., Ruel HLM., Watanabe R., Monteiro BP., Cagnardi P., Steagall PV. Pharmacokinetics of Bupivacaine Following Administration by an Ultrasound-Guided Transversus Abdominis Plane Block in Cats Undergoing Ovariohysterectomy. Pharmaceutics. (2022) PMID: 35893804.

4. Kang W., Gaudette F., Bédard D., Beaudry F., Huot P. Quantitative determination of LY-404,039, a metabotropic glutamate 2/3 receptor agonist, in rat plasma using chemical derivatization and HPLC-MRM/MS. Biomedical Chromatography (2022) PMID: 35684931.

5. Ding S., Ullah  I., Gong Y.G., Grover R.G., Mohammadi M., Chen Y., Vézina D., Beaudoin-Bussières G., Verma V.T., Goyette G., Gaudette F., Richard J., Yang D., Smith III A.B., Pazgier M., Côté M., Abrams C., Kumar P., Mothes W., Uchil P.D., Finzi A. and Baron C. VE607 stabilizes SARS-CoV-2 Spike in the RBD-up conformation and inhibits viral entry. iScience (2022) PMID: 35677392.

6. Shobo A. James N., Dai D., Röntgen A., Black  C., Kwizera J-R., Hancock M.A., Bui K.H. and Multhaup G. The amyloid-β1–42-oligomer interacting peptide D-AIP possesses favorable biostability, pharmacokinetics, and brain region distribution. J. Biol Chem (2021) PMID: 34896396.

7. Grangeon A., Clermont V., Barama A., Gaudette F., Turgeon J. and Michaud V., Determination of CYP450 Expression Levels in the Human Small Intestine by Mass Spectrometry-Based Targeted Proteomics. International Journal of Molecular Sciences (2021) PMID: 34884595.

8. Teyssier V. R., Tournoux F., Simard J-M., Gaudette F., Boudjemeline M., Petrenyov D. R. and DaSilva J. N. Novel O-11C-methylated derivatives of the neprilysin inhibitor sacubritril: Radiosynthesis, autoradiography and plasma stability evaluation. Nuclear Medicine and Biology. (2021) PMID: 34601168.

9. Bonilla A. G., Causeret L. and Torent-Crosa A. Pharmacokinetics of ceftiofur in the metacarpophalangeal joint after standing intravenous regional limb perfusion in horses. Canadian Veterinary Journal (2021) PMID: 34475583.

10. Rajashekar J. K., Richard J., Beloor J., Prévost  J., Anand S. P., Beaudoin-Bussières G., Shan L., Herndler-Brandstetter D., Gendron-Lepage G., Medjahed H., Bourassa C., Gaudette F., Ullah I., Symmes K., Peric A., Lindemuth E., Bibollet-Ruche F., Park J., Chen H-C., Kaufmann D. E., Hahn B. H., Sodroski J., Pazgier M., Flavell R. A., Smith III  A. B., Finzi A. and Kumar P. Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir. Cell Host and Microbe (2021) PMID: 34019804.

11. Mongeau-Pérusse V., Brissette S., Bruneau J., Conrod  P., Dubreucq S., Gazil  G., Stip E. and Jutras-Aswad D. Cannabidiol as a treatment for craving and relapse in individuals with cocaine use disorder: a randomized placebo-controlled trial. Addiction (2021) PMID: 33464660.

12. Ruel H. L. M., Watanabe R., Evangelista M. C., Beauchamp G., Auger J-P., Segura M. and Steagall P. V. Pain burden, sensory profile and inflammatory cytokines of dogs with naturally-occurring neuropathic pain treated with gabapentin alone or with meloxicam. PLoS ONE (2020) PMID: 33253197.

13. Kwan C., Nuara  S. G., Bédard D., Gaudette  F., Gordon J.C., Beaudry F. and Huot P. Selective blockade of the 5Autho-HT3 receptor acutely alleviates dyskinesia and psychosis in the parkinsonian marmoset. Neuropharmacology (2021) PMID: 33152452.

14. Alonso Martinez L. M. and DaSilva J. N. Development of a novel [18F]fluorobenzyl derivative of the AT 1 receptor antagonist Candesartan. J Label Compd Radiopharm (2020) PMID: 33084079.

15. Frouni I., Gaudette  F., Bédard D., Nuara  S. G., Kwan C., Hamadjida A., Gourdon J. C., Beaudry F. and Huot P. Development and validation of a sensitive HPLC-HESI-MS/MS method for quantitative determination of bitopertin in rat and marmoset plasma. MNI Open Res 2020, 4:2 (

16. Dornan M. H., Petrenyov D., Simard J-M., Boudjemeline M., Mititelu R., DaSilva J. N. and Bélanger A.  P. Synthesis of a 11C-Isotopologue of the B-Raf-Selective Inhibitor Encorafenib Using In-Loop [11C]CO2 Fixation. ACS Omega (2020) PMID: 32875231.

17. Abreu Diaz A. M., Drumeva  G. O., Petrenyov D. R., Carrier J-F. and DaSilva J. N. Synthesis of the Novel AT1 Receptor Tracer [18F]Fluoropyridine–Candesartan via Click Chemistry. ACS Omega (2020) PMID: 32832788.

18. Steagall P. V., Ruel H. L. M., Yasuda T., Monteiro B. P., Watanabe R., Evangelista M. C. and Beaudry F. Pharmacokinetics and analgesic effects of intravenous, intramuscular or subcutaneous buprenorphine in dogs undergoing ovariohysterectomy: a randomized, prospective, masked, clinical trial. BMC Vet Res. (2020) PMID: 32448336.

19. Kwan C., Bédard D., Frouni I., Gaudette F., Beaudry F., Hamadjida A and Huot P. Pharmacokinetic profile of the selective 5-HT3 receptor antagonist ondansetron in the rat: an original study and a mini-review of the behavioural pharmacological literature in the rat. Can J PhysiokPharmacol (2020) PMID 32017606.

20. Sid-Otmane L., Hamadjida A., Nuara S. G., Bédard D., Gaudette F., Gourdon J. C., Michaud  V., Beaudry F., Panisset M. and Huot P. Selective metabotropic glutamate receptor 2 positive allosteric modulation alleviates L-DOPA-induced psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset. Eur J Pharmacol (2020) PMID: 32004527.

21. Teyssier V. R., Simard J-M., Dornan M. H., Tournoux F., and DaSilva J. N. Radiosynthesis of the 11C-methyl derivative of LBQ657 for PET investigation of the neprilysin inhibitor sacubitril. J Label Compd Radiopharm (2020) PMID: 31912556.

22. Frouni I., Hamadjida  A., Kwan C., Bédard D., Nafade V., Gaudette F., Nuara S. G., Gourdon J. C., Beaudry  F. and Huot P. Activation of mGlu2/3 receptors, a novel therapeutic approach to alleviate dyskinesia and psychosis in experimental parkinsonism. Neuropharmacology (2019) PMID: 31351976.

23. Gaudette F., Bédard D., Kwan C., Frouni I., Hamadjida A., Beaudry F. and Huot P. Highly sensitive HPLC-MS/MS assay for the quantification of ondansetron in rat plasma and rat brain tissue homogenate following administration of a very low subcutaneous dose. Journal of Pharmaceutical and Biomedical Analysis (2019) PMID: 31330277.

24. Gravel S., Panzini  B., Bélanger F., Turgeon J. and Michaud V. A Pilot Study towards the Impact of Type 2 Diabetes on the Expression and Activities of Drug Metabolizing Enzymes and Transporters in Human Duodenum. International Journal of Molecular Sciences (2019) PMID: 31269743.

25. Grangeon A., Clermont V., Barama A., Gaudette F., Turgeon  J. and Michaud V. Development and validation of an absolute protein assay for the simultaneous quantification of fourteen CYP450s in human microsomes by HPLC-MS/MS-based targeted proteomics. Journal of Pharmaceutical and Biomedical Analysis (2019) PMID: 31125949.

26. Gravel S. Chiasson J-L., Turgeon J., Grangeon A. and Michaud V. Modulation of CYP450 Activities in Patients with Type 2 Diabetes. Clinical Pharmacology & Therapeutics (2019) PMID: 31099895.

27. Bessonnat A., Picotte K. and Lavoie J-P. Intra-articular triamcinolone acetonide improves lung function in horses with severe asthma. Equine Vet. J. (2019) PMID 31006122.

28. Gravel S., Chiasson J-L., Gaudette  F., Turgeon J. and Michaud V. Use of 4ß-Hydroxycholesterol Plasma Concentrations as an Endogenous Biomarlker of CYP3A Activity: Clinical Validation in Individuals with Type 2 Diabetes. Clinical Pharmacology & Therapeutics (2019) PMID: 31002385.

29. Clermont V., Grangeon  A., Barama A., Turgeon J. Lallier M., Malaise J and Michaud V. Activity and mRNA expression levels of selected cytochromes P450 in various sections of the human small intestine. British Journal of Clinical Pharmacology (2019) PMID: 30817016.

30. Frouni I., Kwan C., Bédard D., Belliveau S., Bourgeois-Cayer É., Gaudette F., Beaudry F, Hamadjida A. and Huot P.Effect of the selective 5-HT2A receptor antagonist EMD-281,014 on L-DOPA-induced abnormal involuntary movements in the 6-OHDA-lesioned rat. Experimental Brain Research (2019) PMID: 30298296

31. Dornan M. H., Petrenyov  D., Simard J-M., Aliaga A., Xiong  G., Ghislain  J., Bedell  B., Poitout V. and DaSilva  J. N. A high molar activity 18F-labeled TAK-875 derivative for PET imaging of pancreatic ß-cells. EJNMMI Radiopharmacy and Chemistry (2018) DOI

32. Gaudette F., Hamadjida A., Bédard D., Nuara S. G., Gourdon J. C., Michaud V., Beaudry F. and Huot P. Development of a selective and sensitive high-performance liquid chromatography-tandem mass spectrometry assay to support pharmacokinetic studies of LY-487,379 in rat and marmoset. Journal of Chromatography B (2018) PMID: 29980099.

33. Hamadjida A., Nuara  S. G., Bédard D., Gaudette F., Beaudry F., Gourdon J. C. and Huot P. The highly selective 5-HT2A  antagonist EMD-281,014 reduces dyskinesia and psychosis in the L-DOPA-treated parkinsonian marmoset. Neuropharmacology (2018) PMID: 29969592.

34. Benito J., Monteiro B., Beaudry  F. and Steagall P. Efficacy and pharmacokinetics of bupivacaine with epinephrine or dexmedetomidine after intraperitoneal administration in cats undergoing ovariohysterectomy. Canadian Journal of Veterinary Research (2018) PMID: 29755192.

35. Dornan  M. H., Simard J-M., Leblond A., Juneau D., Delouya  G., Saad F., Ménard C. and DaSilva J. N. Simplified and robust one-step radiosynthesis of [18 F]DCFPyL via direct radiofluorination and cartridge-based purification. Journal of Labelled Compounds Radiopharmarceuticals (2018) PMID: 29722070.

36. Huguet J., Gaudette F., Michaud V. and Turgeon J. Development and validation of probe drug cocktails for the characterization of CYP450- mediated metabolism by human heart microsomes. Xenobiotica (2018) PMID: 29448869.

37. Maximos S., Chamoun M., Gravel S., Turgeon J. and Michaud V. Tissue specific modulation of cyp2c and cyp3a mRNA level and activities by diet induced obesity in mice: the impact of type 2 diabetes on drug metabolizing enzymes in liver and extra-hepatic tissues. Pharmaceutics (2017) PMID: 28954402.

38. Gaudette F., Hamadjida A., Bédard  D., Nuara S. G., Beaudry F. and Huot P. Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method to quantify LY-354,740 in rat and marmoset plasma. Journal of Chromatography B (2017) PMID: 28802219.

39. Doodnaught G. M., Monteiro B. P., Benito J., Edge D., Beaudry F., Pelligand L. and Steagall P. Pharmacokinetic and pharmacodynamic modeling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats. PLoS ONE (2017) PMID: 28445495.

40. Grangeon A., Gravel S., Gaudette F., Turgeon J. and Michaud V. Highly sensitive LC-MS/MS methods for the determination of seven human CYP450 activities using small oral doses of probe drugs in human. Journal of Chromatography B (2017) PMID: 27978469.

41. Benito J., Monteiro B.  P., Beaudry  F., Lavoie A-M., Lascelles B. D. X. and Steagall P. V. Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy. Am J Vet Res (2016) PMID: 27227503.

42. Lu J., Grangeon A., Gaudette  F., Turgeon J. and Michaud V. Effects of Tricyclic Compounds on the Transport of Anti-migraine Triptans through Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2). Journal of Pharmacokinetics & Experimental Therapeutics, 1(106):1-11 (2016)

43. Huguet J., Lu J., Gaudette F., Chiasson J-L., Hamet P., Michaud V. and Turgeon J. No effects of pantoprazole on the pharmacokinetics of rosuvastatin in healthy subjects. European Journal of Clinical Pharmacology, 72(8):925-31 (2016) PMID: 27146814.

44. Gaudette F., Sirhan-Daneau  A., St-Onge M., Turgeon J. and Michaud V. Development of a sensitive method for the determination of oxycodone and its major metabolites noroxycodone and oxymorphone in human plasma by liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 1008:174-180 (2016) PMID: 26655109.

45. Gaudette F., Benito J., Steagall P. and Beaudry F. Assessment of tandem mass spectrometry and high-resolution mass spectrometry for the analysis of bupivacaine in plasma. Biomedical Chromatography, 29:1724-1730 (2015) PMID: 25963121

46. Lu J., Michaud V., Guillarte Moya L.  G., Gaudette F., Leung Y. H. and Turgeon J. Effects of beta-blockers and tricyclic antidepressants on the activity of human organic anion transporting polypeptide 1A2 (OATP1A2). Journal of Pharmacology and Experimental Therapeutics, 352:552–558 (2015) PMID: 25563901.


Cette information est-elle utile?
Laissez-nous savoir comment nous pouvons améliorer le site pour mieux répondre à vos besoins.