Identification of the mechanisms of motor neuron degeneration in the nervous system, particularly in the case of amyotrophic lateral sclerosis (ALS).

Evaluation of misfolded SOD1 and mitochondrial dysfunction in ALS.

RNA binding proteins such as TDP-43, FUS, and other hnRNP family members in ALS pathogenesis, Stress granules and processing bodies.

Complementary and multidisciplinary approaches involving transgenic rodent models, tissue cultures, and isolated organelles are used. Technologies include biochemistry, cellular biology, proteomics, immunocytochemistry and advanced microscopy (confocal and electron).