Vande Velde, Christine

Principal scientist

CHUM Research Centre

Research theme

Associate professor
Department of neurosciences, Université de Montréal

Accredited professor
Department of biochemistry, Université de Montréal

514 890-8000, ext. 28832

Web site :

The patient who needs immediate assistance should not communicate directly with the researcher. Instead, they should call the doctor’s office or take other appropriate measures, such as going to the nearest emergency service.

Other affiliations

Central nervous system research group

Applied medical genetics network


Neurodegeneration, amyotrophic lateral sclerosis, motor neurons, mitochondria, stress granules, processing bodies, central nervous system, biochemistry, cell and molecular biology, imaging.

Research interests

Identification of the mechanisms of motor neuron degeneration in the nervous system, particularly in the case of amyotrophic lateral sclerosis (ALS).

Evaluation of misfolded SOD1 and mitochondrial dysfunction in ALS.

RNA binding proteins such as TDP-43, FUS, and other hnRNP family members in ALS pathogenesis, Stress granules and processing bodies.

Complementary and multidisciplinary approaches involving transgenic rodent models, tissue cultures, and isolated organelles are used. Technologies include biochemistry, cellular biology, proteomics, immunocytochemistry and advanced microscopy (confocal and electron).




ALS: decoding its molecular mechanisms to improve treatment