Centre de recherche du CHUM
Department of Neuroscience, Université de Montréal
514-890-800, ext.: 12731
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The lab focuses on different aspects of astrocyte-neuron interactions. In particular we study the effects of stress on astrocyte structure and function. We use an array of stress paradigms in an attempt to model different aspects of stress-disorders such as anxiety, PTSD, and depression. Our goal is to reveal how the effects of stress on astrocytes influences neuronal function and output, which in turn underlies behaviour.
We are also interested in the link between astrocyte metabolism and synaptic plasticity, investigating the specific conditions under which neurons rely upon astrocytes for energetic substrates, gliotransmitters, as well as clearance of neurotransmitters and metabolites. The lab has active collaborations to develop the next generation of tools to understand astrocyte metabolism.
We use complimentary techniques combining two-photon microscopy, electrophysiology, in vivo imaging, and behaviour.