Murphy Royal, Ciaran

Ph.D.

Principal scientist

Centre de recherche du CHUM

Research theme

Assistant professor
Department of Neuroscience, Université de Montréal

Contact

ciaran.murphy-royal@umontreal.ca
514-890-800, ext.: 12731

Lab Website

Twitter

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Keywords

Glia-neuron interactions
Astrocytes
Synaptic plasticity
Synaptic metabolism
Stress response

Research interests

The lab focuses on different aspects of astrocyte-neuron interactions. In particular we study the effects of stress on astrocyte structure and function. We use an array of stress paradigms in an attempt to model different aspects of stress-disorders such as anxiety, PTSD, and depression. Our goal is to reveal how the effects of stress on astrocytes influences neuronal function and output, which in turn underlies behaviour.

We are also interested in the link between astrocyte metabolism and synaptic plasticity, investigating the specific conditions under which neurons rely upon astrocytes for energetic substrates, gliotransmitters, as well as clearance of neurotransmitters and metabolites. The lab has active collaborations to develop the next generation of tools to understand astrocyte metabolism.

We use complimentary techniques combining two-photon microscopy, electrophysiology, in vivo imaging, and behaviour.

Publications

PubMed
Google Scholar