The CRCHUM’s Cellular Imaging Core Facility has contributed to the publication of a large number of scientific articles since 2016.


  • Levert, S., Pilliod, J., Aumont, É. et al. Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells. Mol Neurobiol 60, 1021–1039 (2023).
  • Ifeoluwa I. Adedipe, Lewis R. Depaauw-Holt, Jade Latraverse-Arquilla, Juliette Vaugeois, Manon Duquenne, Benjamin Rogers, Sarah Peyrard, Anthony Bosson, Ciaran Murphy-Royal. Astrocyte glucocorticoid signaling mediates cognitive impairment induced by early-life stress. bioRxiv 2022.12.11.519598; doi:


  • Lemaître, F., Farzam-kia, N., Carmena Moratalla, A. et al. IL-27 shapes the immune properties of human astrocytes and their impact on encountered human T lymphocytes. J Neuroinflammation 19, 212 (2022).
  • Geoffroy, K.; Laplante, P.; Clairefond, S.; Azzi, F.; Trudel, D.; Lattouf, J.-B.; Stagg, J.; Saad, F.; Mes-Masson, A.-M.; Bourgeois-Daigneault, M.-C.; et al. High Levels of MFG-E8 Confer a Good Prognosis in Prostate and Renal Cancer Patients. Cancers 2022, 14, 2790. cancers14112790
  • Paim, L.M.G., FitzHarris, G. Cell size and polarization determine cytokinesis furrow ingression dynamics in mouse embryos | Proceedings of the National Academy of Sciences. March 16, 2022; 119 (12) e2119381119.
  • Beillevaire, D., Migneault, F., Turgeon, J. et al. Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes. Cell Death Dis 13, 145 (2022).
  • Antoine Philippe Fournier, Stephanie Zandee, Marc Charabati, Evelyn Peelen, Olivier Tastet, Jorge Ivan Alvarez, Hania Kebir, Lyne Bourbonnière, Sandra Larouche, Boaz Lahav, Wendy Klement, Fiona Tea, Alain Bouthillier, Robert Moumdjian, Romain Cayrol, Pierre Duquette, Marc Girard, Catherine Larochelle, Nathalie Arbour, Alexandre Prat. CLMP Promotes Leukocyte Migration Across Brain Barriers in Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm Nov 2022, 9 (6) e200022; DOI: 10.1212/NXI.0000000000200022
  • Abdelnabi, Mohamed N. Flores Molina, Manuel, Soucy, Geneviève, Quoc-Huy Trinh, Vincent, Bédard, Nathalie, Mazouz, Sabrina, Jouvet, Nathalie, Dion, Jessica, Tran, Sarah, Bilodeau, Marc, Estall, Jennifer L. Shoukry, Naglaa H. Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis. Cellular and Molecular Gastroenterology and Hepatology, 2022-01-01, Volume 14, Issue 6, Pages 1269-1294,


  • Lemaître F, Carmena Moratalla A, Farzam-kia N, Carpentier Solorio Y, Tastet O, Cleret-Buhot A, Guimond JV, Haddad E and Arbour N (2021) Capturing T Lymphocytes’ Dynamic Interactions With Human Neural Cells Using Time-Lapse Microscopy. Front. Immunol. 12:668483. doi: 10.3389/fimmu.2021.668483
  • Anand, S.P.; Prévost, J.; Descôteaux-Dinelle, J.; Richard, J.; Nguyen, D.N.; Medjahed, H.; Chen, H.-C.; Smith, A.B., III; Pazgier, M.; Finzi, A. HIV-1 Envelope Glycoprotein Cell Surface Localization Is Associated with Antibody-Induced Internalization. Viruses 2021; 13, 1953.
  • Doreille A, Azzi F, Larivière-Beaudoin S, Karakeussian-Rimbaud A, Trudel D, Hébert MJ, Dieudé M, Patey N, Cardinal H. Acute Kidney Injury, Microvascular Rarefaction, and Estimated Glomerular Filtration Rate in Kidney Transplant Recipients. Clin J Am Soc Nephrol. 2021 Mar 8;16(3):415-426. doi: 10.2215/CJN.07270520. PMID: 33648972; PMCID: PMC8011007.
  • Guo Q, Bartish M, Gonçalves C, Huang F, Smith-Voudouris J, Krisna SS, Preston SEJ, Emond A, Li VZ, Duerr CU, Gui Y, Cleret-Buhot A, Thebault P, Lefrère H, Lenaerts L, Plourde  D, Su J, Mindt  BC, Hewgill SA, Cotechini T, Hindmarch CCT, Yang W, Khoury E, Zhan Y, Narykina V, Wei Y, Floris G, Basik M, Amant F, Quail DF, Lapointe R, Fritz JH, Del Rincon SV, Miller WH Jr. The MNK1/2-eIF4E Axis Supports Immune Suppression and Metastasis in Postpartum Breast Cancer. Cancer Res. 2021 Jul 15;81(14):3876-3889. doi: 10.1158/0008-5472.CAN-20-3143. Epub 2021 May 11. PMID: 33975880.
  • Brodeur, M.N., Simeone, K., Leclerc-Deslauniers, K. et al. Carboplatin response in preclinical models for ovarian cancer: comparison of 2D monolayers, spheroids, ex vivo tumors and in vivo models. Sci Rep 11, 18183 (2021).
  • Hadjara Sidibé, Yousra Khalfallah, Shangxi Xiao, Nicolás B Gómez, Hana Fakim, Elizabeth M H Tank, Geneviève Di Tomasso, Eric Bareke, Anaïs Aulas, Paul M McKeever, Ze’ev Melamed, Laurie Destroimaisons, Jade-Emmanuelle Deshaies, Lorne Zinman, J Alex Parker, Pascale Legault, Martine Tétreault, Sami J Barmada, Janice Robertson, Christine Vande Velde, TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia, Brain, Volume 144, Issue 11, November 2021, Pages 3461–3476,
  • Gagné M, Deshaies J-E, Sidibé H, Benchaar Y, Arbour D, Dubinski A, Litt G, Peyrard S, Robitaille R, Sephton CF and Vande Velde C (2021) hnRNP  A1B, a Splice Variant of HNRNPA1, Is Spatially and Temporally Regulated. Front. Neurosci. 15:724307. doi: 10.3389/fnins.2021.724307


  • Bernard M, Cardin GB, Cahuzac M, Ayad T, Bissada E, Guertin L, Bahig H, Nguyen-Tan PF, Filion E, Ballivy O, Soulieres D, Rodier F, Christopoulos A. Dual Inhibition of Autophagy and PI3K/AKT/MTOR Pathway as a Therapeutic Strategy in Head and Neck Squamous Cell Carcinoma. Cancers. 2020; 12(9):2371.
  • Mohamed, B., Mazeaud, C., Baril, M. et al. Very-long-chain fatty acid metabolic capacity of 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) promotes replication of hepatitis C virus and related flaviviruses. Sci Rep 10, 4040 (2020).
  • Julie Pilliod, Alexandre Desjardins, Camille Pernègre, Hélène Jamann, Catherine Larochelle, Edward A. Fon, Nicole Leclerc. Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion. Journal of Biological Chemistry. Volume 295, Issue 51, 2020, Pages 17827-17841. ISSN 0021-9258.
  • Bieke Broux, Stephanie Zandee, Elizabeth Gowing, Marc Charabati, Marc-André Lécuyer, Olivier Tastet, Lamia Hachehouche, Lyne Bourbonnière, Jean-Philippe Ouimet, Florent Lemaitre, Sandra Larouche, Romain Cayrol, Alain Bouthillier, Robert Moumdjian, Boaz Lahav, Josée Poirier, Pierre Duquette, Nathalie Arbour, Evelyn Peelen, Alexandre Prat. Interleukin-26, preferentially produced by TH17 lymphocytes, regulates CNS barrier function. Neurol Neuroimmunol Neuroinflamm Nov 2020, 7 (6) e870; DOI: 10.1212/NXI.0000000000000870
  • Molina, M. F., Fabre, T., Cleret-Buhot, A., Soucy, G., Meunier, L., Abdelnabi, M. N., Belforte, N., Turcotte, S., Shoukry, N. H. Visualization, Quantification, and Mapping of Immune Cell Populations in the Tumor Microenvironment. J. Vis. Exp. (157), e60740, doi:10.3791/60740 (2020).
  • Nouredin Messaoudi, Isabelle Cousineau, Elizabeth Arslanian, David Henault, David Stephen, Franck Vandenbroucke-Menu, Michel Dagenais, Richard Létourneau, Marylène Plasse, André Roy, Réal Lapointe, Dirk Ysebaert, Dominique Trudel, Geneviève Soucy, John Stagg & Simon Turcotte (2020) Prognostic value of CD73 expression in resected colorectal cancer liver metastasis, OncoImmunology, 9:1, DOI: 10.1080/2162402X.2020.1746138
  • Amate M, Goldgewicht J, Sellamuthu B, Stagg J, Yu FTH. The effect of ultrasound pulse length on microbubble cavitation induced antibody accumulation and distribution in a mouse model of breast cancer. Nanotheranostics. 2020 Sep 15;4(4):256-269. doi: 10.7150/ntno.46892. PMID: 33033688; PMCID: PMC7532643.


  • Legroux L, Moratalla AC, Laurent C, Deblois G, Verstraeten SL and Arbour N (2019) NKG2D and Its Ligand MULT1 Contribute to Disease Progression in a Mouse Model of Multiple Sclerosis. Front. Immunol. 10:154. doi: 10.3389/fimmu.2019.00154
  • Fabiana C.P. Valera, Manon Ruffin, Damien Adam, Émilie Maillé, Badr Ibrahim, Julie Berube, Simon Rousseau, Emmanuelle Brochiero, Martin Y. Desrosiers, Staphylococcus aureus impairs sinonasal epithelial repair: Effects in patients with chronic rhinosinusitis with nasal polyps and control subjects, Journal of Allergy and Clinical Immunology, Volume 143, Issue 2, 2019, Pages 591-603.e3, ISSN 0091-6749,
  • Paim, L.M.G., FitzHarris, G. Tetraploidy causes chromosomal instability in acentriolar mouse embryos. Nat Commun 10, 4834 (2019).
  • Zaoui, K., Boudhraa, Z., Khalifé, P. et al. Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion. Nat Commun 10, 2666 (2019).
  • Tessa Dhaeze, Catherine Lachance, Laurence Tremblay, Camille Grasmuck, Lyne Bourbonnière, Sandra Larouche, Olivia Saint-Laurent, Marc-André Lécuyer, Rose-Marie Rébillard, Stephanie Zandee and Alexandre Prat. Sex-dependent factors encoded in the immune compartment dictate relapsing or progressive phenotype in demyelinating disease. JCI Insight. 2019;4(6):e124885.
  • Liao M, Kundap U, Rosch RE, Burrows DRW, Meyer MP, Ouled Amar Bencheikh B, Cossette P, Samarut É. Targeted knockout of GABA-A receptor gamma 2 subunit provokes transient light-induced reflex seizures in zebrafish larvae. Dis Model Mech. 2019 Nov 11;12(11):dmm040782. doi: 10.1242/dmm.040782. PMID: 31582559; PMCID: PMC6899022.


  • Yang B, Lan S, Dieudé M, Sabo-Vatasescu JP, Karakeussian-Rimbaud A, Turgeon J, Qi S, Gunaratnam L, Patey N, Hébert MJ. Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2018 Jul;29(7):1900-1916. doi: 10.1681/ASN.2017050581. Epub 2018 Jun 20. PMID: 29925521; PMCID: PMC6050936.
  • Doyle, J.J., Parker, J.A. (2018). Methods to Investigate the Molecular Basis of Progranulin Action on Neurons In Vivo Using Caenorhabditis elegans. In: Bateman, A., Bennett, H., Cheung, S. (eds) Progranulin. Methods in Molecular Biology, vol 1806. Humana Press, New York, NY.
  • Hania Kebir, Lionel Carmant, François Fontaine, Kathie Béland, Ciprian M. Bosoi, Nathalie T. Sanon, Jorge I. Alvarez, Sébastien Desgent, Camille L. Pittet, David Hébert, Marie-Josée Langlois, Rose-Marie Rébillard, Dang K. Nguyen, Cécile Cieuta-Walti, Gregory L. Holmes, Howard P. Goodkin, John R. Mytinger, Mary B. Connolly, Alexandre Prat and Elie Haddad. Humanized mouse model of Rasmussen’s encephalitis supports the immune-mediated hypothesis. J Clin Invest. 2018;128(5):2000-2009.
  • Deshaies JE, Shkreta L, Moszczynski AJ, Sidibé H, Semmler S, Fouillen A, Bennett ER, Bekenstein U, Destroismaisons L, Toutant J, Delmotte Q, Volkening K, Stabile  S, Aulas A, Khalfallah Y, Soreq H, Nanci A, Strong MJ, Chabot B, Vande Velde C. TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis. Brain. 2018 May 1;141(5):1320-1333. doi: 10.1093/brain/awy062. PMID: 29562314; PMCID: PMC5917749.
  • Khalfallah, Y., Kuta, R., Grasmuck, C. et al. TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types. Sci Rep 8, 7551 (2018).
  • Agostinone J, Alarcon-Martinez L, Gamlin C, Yu WQ, Wong ROL, Di Polo A. Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury. Brain. 2018 Jul 1;141(7):1963-1980. doi: 10.1093/brain/awy142. PMID: 29931057; PMCID: PMC6022605.


  • Tremblay N, Baril M, Chatel-Chaix L, EsSaad S, Park AY, Koenekoop RK, et al. (2016) Spliceosome SNRNP200 Promotes Viral RNA Sensing and IRF3 Activation of Antiviral Response. PLoS Pathog 12(7): e1005772. doi:10.1371/journal. ppat.1005772
  • Pickles, S., Semmler, S., Broom, H.R. et al. ALS-linked misfolded SOD1 species have divergent impacts on mitochondria. acta neuropathol commun 4, 43 (2016).



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