Pharmacokinetics

Considered to be the reference instrument for quantification due to its high selectivity and sensitivity. Mainly used for trace and ultra-trace quantification of xenobiotics and metabolites in biological fluids and tissues. AIM technology allows unrivalled limits of detection (LOD) and quantification (LOQ) to be achieved in complex matrices. 

Chromatographic system: Dionex UltiMate™ RSLC UHPLC by Thermo Scientific™ 

Ionisation sources: ESI, APCI 

Possible applications:  

• Quantitative analysis of small molecules 
• Analysis of xenobiotics and metabolites in support of PK/PD studies 
• Analysis of preclinical and clinical samples 

Allows targeted or non-targeted qualitative and quantitative analyses at very high resolution and high mass accuracy of drugs, metabolites, degradation products, toxins and other molecules in biological, environmental or formulation matrices.

Chromatographic systems:  

Dionex UltiMate™ RSLC UHPLC by Thermo Scientific™

Ionisation sources: ESI, APCI, nanospray 

Possible applications:  

• Exact mass analysis 
• Identification and characterization of degradation products and metabolites 
• Qualitative and quantitative analysis of small molecules and proteins