Hassan FAHMI

Hassan FAHMI

Publications

The patient who needs immediate assistance should not communicate directly with the researcher. Instead, they should call the doctor’s office or take other appropriate measures, such as going to the nearest emergency service.

Jobs

Accredited member Programmes de biologie moléculaire et sciences biomédicales, Université de Montréal

Associate professor Department of medicine, Université de Montréal

Other Affiliations

Member American Society for Biochemistry and Molecular Biology

Member OsteoArthritis Research Society International

Member Canadian Arthritis Network

Research Interests

Our studies are aimed at defining the mechanisms involved in the onset, duration and resolution of inflammatory and catabolic events in articular joint tissues, with the ultimate goal of identifying novel molecular targets for the treatment or prevention of osteoarthritis. Current laboratory projects include: 

  • Role of PPARgamma in osteoarthritis: PPARgamma is a ligand-activated transcription factor belonging to the nuclear receptor superfamily and plays important roles in the regulation of several cellular processes. We have shown that PPARgamma activators downregulated the expression of several genes considered essential in the pathogenesis of osteoarthritis and were protective in animal models of the disease. Our laboratory is further characterizing the role of PPARgamma in osteoarthritis with a particular emphasis on the mechansims that regulate PPARgamma expression. Additional studies are aimed at understanding the exact molecular mechanisms by which PPARgamma activation modulates gene expression. Elucidating these issues will improve our understanding of the role of PPARgamma in osteoarthritis and will be helpful in the developpement of new therapeutic strategies. 
  • Expression and function of mPGES-1 in articular tissues: mPGES-1 catalyzes the terminal step in the biosynthesis of PGE2, which plays critical roles in the pathogenesis of osteoarthritis. Studies from our laboratory and others indicate that inhibition of mPGES-1 is a promising therapeutic target in osteoarthritis. Our objective is to characterize the molecular mechanisms involved in the regulation of mPGES-1 gene expression, with a particular emphasis on the role of epigenetic modifications. 
  • Genetic studies in osteoarthritis: Although the etiology and the molecular aspects of the pathogenesis of osteoarthritis are unknown, epidemiological and genetic studies have demonstrated that genetic factors are strong determinants of osteoarthritis. Therefore, identifying genes that may be involved in osteoarthritis is a promising approach to understand the molecular basis and pathogenesis of the disease. We are studying the role of genetic variation in a number of candidate genes. Our goal is to identify functionally significant genetic variations that play a role in the susceptibility to and/or severity of osteoarthritis.

Immunopathology

The Immunopathology Research Theme comprises a group of researchers spanning the basic and clinical research continuum and focusing on the immune/inflammatory processes involved in the disturbance and restoration of homeostasis. These activities are rooted in shared visions regarding explorat…

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Manipulations de laboratoire