CHUM Research Centre
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Department of medicine, Faculty of medicine
Department of clinical science, intervention and technology, Division of obstetrics and gynecology, Karolinska Institutet, Stockholm Sweden
Single-cell genomics, reproduction and development, fetal programming, molecular and cellular biology, transgenerational inheritance, epigenetics, embryo development.
- Investigate how ‘insults’ during the preimplantation environment can modify the ‘omics’ (methylome, transcriptome and noncoding RNAs) of the first three lineages at single cell resolution and how these alterations reprogram the placenta and developing fetus, ultimately leading to disease and disorder later in life.
- Investigate the impact of adjuvant therapies and ex vivo environment on preimplantation embryos, as occurring in Artificial Reproduction (ART).
- Unravel fundamental aspects of the mammalian preimplantation embryo development and RNA biology.
- Investigate the mechanism(s) underlying lineage formation in the mammalian embryo at a single-cell resolution.