Grandvaux, Nathalie

Principal scientist

CHUM Research Centre

Research theme

Immunopathology

Associate scientific director
Student and postdoctoral affairs, CRCHUM

Director
Host Response to Viral Infections Laboratory, CRCHUM

Professor
Department of biochemistry and molecular medicine, Université de Montréal

Website: www.nathaliegrandvauxlab.com

Contact

nathalie.grandvaux@umontreal.ca
514 890-8000, ext. 35292 (office) - ext. 35436 (lab)

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Other affiliations

Adjunct professor
Department of microbiology and immunology, Université de Montréal
Department of microbiology and immunology, McGill university

Keywords

Viral infections, antivirals, inflammation, cytokines, gene regulation, cell signaling, redox, post-translational modifications of proteins, proteomics.

Research interests

Viruses are a threat to human health that worsens with new epidemics and the emergence of new viruses. An ongoing global effort to combat the virus is to develop host-directed antivirals as an alternative to traditional antiviral drugs that promote the development of resistant viruses. Our research aims to understand the interaction between a virus and host cells to identify mechanisms that could be targeted to develop new antivirals. We pursue several lines of research (website):

To determine the role of redox metabolism in antiviral defense and in the pathogenesis associated with the virus. We use cellular, biochemical and proteomic biology approaches to determine the source and impact of ROS.
To determine the role of autophagy in respiratory syncytial virus (RSV) replication responsible for bronchiolitis and pneumonia in children and the elderly and immunocompromised individuals. We strongly evaluate the effect of autophagy inducers in preclinical studies to determine their antiviral potential.