Rodier, Francis

Principal scientist

CHUM Research Centre

Research theme

Assistant professor
Department of radiology, radio-oncology and nuclear medicine, Université de Montréal

Contact

rodierf@mac.com
514 890-8000, ext. 26939
 

The patient who needs immediate assistance should not communicate directly with the researcher. Instead, they should call the doctor’s office or take other appropriate measures, such as going to the nearest emergency service.

Keywords

Biomarkers, chemotherapy, cell fate, cell death, cell senescence, radiation, DNA damage repair, DNA damage response signaling, telomeres, anti-cancer therapy, aging and cancer.

Research interests

The laboratory focuses it's research on identifying cellular and tissue mediators of the mammalian DNA damage response. This important biological phenomenon is involved in human aging, cancer development, and influences the outcome of cancer therapy.

More specifically, we want to understand how the DNA damage response is terminated following DNA lesion repair, and how cancer cells can often tolerate persistent DNA damage signalling that occurs when DNA lesions are irreparable. To achieve these goals, we combine cell culture and animal/human models with cutting edge scientific tools.  In collaboration with clinicians, we are also working to develop new molecular diagnostic tools for cancer detection and we are trying to identify cellular targets to sensitize cancer cells to chemotherapy or radiotherapy.

Publications

Publications indexed on PubMed

News

Controlling "inflammaging"

2019 CRCHUM Awards of Excellence: A Great Vintage

Recherche en oncologie de précision : 1 million de $ pour une équipe codirigée par la Dre Diane Provencher (In French only)

A “one-two punch” to wipe out cancerous ovarian cells