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Chief Molecular genetics laboratory, CRCHUM

Full professor Department of medicine, Université de Montréal

Research Interests

The pathogenesis of cardiovascular diseases, such as hypertension, cardiac, aortic and renal hypertrophy and hyperplasia. Focus on identifying quantitative trait loci (QTLs) using a combined approach of genetics, genomics, congenics, transgenics, knockouts, in situ hybridization, gene profiling and any new technology that is appropriate for gene identification. Moreover, we are interested in analyzing QTL-QTL interactions (see Hypertension 49:740, 2007 and other recent publications on Medline).

The specific animal model tested in our lab is the Dahl salt-sensitive hypertensive rat. At present, our group is the primary research centre in the world that is employing this model for hypertension QTL identifications and for QTL-QTL interactions.


Metabolic diseases, including obesity and diabetes, are major risk factors for the development of several chronic diseases, including cardiovascular diseases, and are the leading causes of mortality and morbidity in Western countries. The research components of this multidisciplinary axis foc…

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