John S D CHAN

John S D CHAN

Publications

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Jobs

Director Laboratory of molecular nephrology and endocrinology, CRCHUM

Professor (Research) Department of medicine, Université de Montréal

Research Interests

The research interests of Dr. John S.D. Chan are the role of intrarenal renin-angiotensin system (RAS) and reactive oxygen species in the pathogenesis of diabetic nephropathy with the emphasis on the expression of angiotensinogen gene and the generation of ROS on tubular apoptosis in diabetes.

Transgenic mice specifically overexpressing angiotensinogen and catalase in the kidney will be used to study the molecular mechanism of action of intrarenal RAS and ROS in the induction of tubular fibrosis and apoptosis in diabetes.

DNA gene chip microarray will be used to identify the differentially expressed genes in the diabetic kidney. The physiological role of these differentially expressed genes will be studied in vitro and in vivo

Cardiometabolic

Metabolic diseases, including obesity and diabetes, are major risk factors for the development of several chronic diseases, including cardiovascular diseases, and are the leading causes of mortality and morbidity in Western countries. The research components of this multidisciplinary axis foc…

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