Number of job available: 1

Project description

Pathogenetic mechanisms of hepatic encephalopathy, a brain complication of liver disease

Our group is interested in studying cerebral complications of liver disease, a neuropsychiatric syndrome called hepatic encephalopathy. The candidate will participate in ongoing projects, combining in vivo, ex vivo and in vitro approaches in order to test new hypotheses as well as new therapeutic approaches in animal models.

Christopher Rose, Ph.D.

Professeur sous octroi titulaire

Faculté de médecine, Université de Montréal

Laboratoire d'hépato-neuro

Centre Hospitalier de l'Université de Montréal (CRCHUM)

https://hepato-neuro.ca

Bibliography

Oliveira M, Monnet-Aimard A, Bosoi CR, Tremblay M, Rose CF. (2022) Sex is associated with differences in oxidative stress and susceptibility to severe hepatic encephalopathy in bile-duct ligated rats. J Neurochem.162:337–351. https://doi.org/10.1111/jnc.15661

Ochoa-Sanchez R, Tamnanloo F, Rose CF (2021) Hepatic Encephalopathy: From Metabolic to Neurodegenerative. Neurochem Res 46:2612–2625. https://doi.org/10.1007/s11064-021-03372-4

Clément M-A, Bosoi CR, Oliveira MM, et al (2021) Bile-duct ligation renders the brain susceptible to hypotension-induced neuronal degeneration: Implications of ammonia. J Neurochem 157:561–573. https://doi.org/10.1111/jnc.15290

Ochoa‐Sanchez R, Oliveira MM, Tremblay M, et al (2021) Genetically engineered E. coli Nissle attenuates hyperammonemia and prevents memory impairment in bile-duct ligated rats. Liver Int 41:1020–1032. https://doi.org/10.1111/liv.14815

Rose CF, Amodio P, Bajaj JS, et al (2020) Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy. J Hepatol 73:1526–1547. https://doi.org/10.1016/j.jhep.2020.07.013

Qualifications

• Candidates must be motivated, ready to take up challenges to obtain a 2^nd or 3^rd cycle degree in biomedical sciences, neurosciences or pharmacology
• Prior research experience and knowledge of English are assets
• Hold a bachelor's or master's degree in health sciences (biology, biochemistry, biomedical sciences, etc.)

Only selected candidates will be contacted for an interview.

The CRCHUM invites women, Aboriginals, visible minorities, ethnic minorities and people with disabilities to apply. The CRCHUM adopts a broad and inclusive definition of diversity that goes beyond applicable laws.