Cell-Intrinsic Resistance to CTL as a Mechanism of HIV Persistence


At the June 11 CRCHUM conference, we will hear from Brad Jones. Dr. Jones received his PhD in Immunology from the University of Toronto, before beginning a post-doctoral fellowship at the Ragon Institute of MGH, MIT, and Harvard in 2012. He currently serves as a Principal Investigator of the NIH-funded Martin Delaney ‘BELIEVE’ collaboratory.

HIV infection persists for life despite antiretroviral therapy (ART), and rebounds from viral reservoirs if ART is interrupted. This ability to persist despite the presence of immune effectors, primarily cytotoxic T-lymphocytes (CTL) is generally attributed to viral latency and/or anatomical sequestration of the reservoir away from CTL. We will present evidence that HIV-specific T-cells continue to be stimulated by antigen at appreciable levels in individuals on long-term ART, underscoring the importance of considering additional barriers to reservoir elimination. We propose that one such barrier is through the selection of reservoir-harboring cells that are resistant to killing by CTL – a phenomenon for which we will present recent mechanistic insights.
 


FRIDAY, JUNE 11, 2021 – 12 P.M. TO 1 P.M. 

> Subscribe to the conference

*You will receive a confirmation email containing the information you need to join the meeting.
 

Dr. Jones is a Viral Immunologist, and an Associate Professor at Weill Cornell Medicine, in the Division of Infectious Diseases. His current research is focused on understanding how to effectively harness innate and adaptive cellular immune responses to contribute to the elimination of the HIV reservoirs that persist in individuals on long-term therapy, and thus to inform efforts to cure infection. Work in the Jones lab has led the discovery of cell-intrinsic resistance to cytotoxic T-cells, as a contributor to HIV persistence on long-term antiretroviral therapy; with ongoing research focused on uncovering and overcoming underlying mechanisms.

Jones Lab - Weill Cornell Medicine


Invited by Nicolas Chomont
Immunopathology Research Theme


We look forward to seeing you connected in large numbers!
 


ABOUT CRCHUM CONFERENCES

The CRCHUM Conferences are free weekly meetings featuring renowned scientific speakers from various disciplines. 

> Schedule of the CRCHUM Conferences