Using numbers to understand adipocyte development and function

On Friday, April 12, 2019, the CRCHUM Conferences will host Gareth Lim, assistant professor at the department of medicine at the University of Montreal and principal scientist at the CRCHUM.


Molecular scaffolds belonging to the 14-3-3 protein family have pleiotropic functions, as they facilitate protein-protein interactions, aid in forming transcriptional complexes, and control protein localization. Their ability to recognize and bind to numerous phosphorylated proteins results in large and diverse interactomes. Collectively, 14-3-3 proteins can regulate numerous physiological processes.

We recently uncovered a critical role of 14-3-3 in adipogenesis, or fat cell development, but given its diverse interactome, we hypothesized that it could influence other aspects of adipocyte function. To this end, we have utilized unbiased approaches, such as proteomics, to elucidate the 14-3-3 interactome and have identified novel processes that underlie adipocyte function and development. By increasing our knowledge of how 14-3-3 influences adipocyte function, it may one day lead to novel approaches to treat metabolic diseases like obesity.

This conference will be presented in English.

Friday, April 12, at noon
Auditorium of the CRCHUM , R05.210 and R05.220
900 Saint-Denis Street, 5th floor 
Montreal (Quebec), H2X 0A9

Gareth Lim, M.D., FRCPC
Assistant professor, Department of medicine, University of Montreal
Principal scientist, CRCHUM
Canada Research Chair in Adipocyte Development

About CRCHUM Conferences

The CRCHUM Conferences are free weekly meetings featuring renowned scientific speakers from various disciplines. These conferences are accredited by the Royal College of Physicians and Surgeons of Canada as continuing professional development activities. 

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