Brain CB1 Receptors: from incidental learning to psychoses and back


On Friday, January 10, 2020, the CRCHUM Conferences will host Giovanni Marsicano, research director INSERM in the NeuroCentre Magendie at Université de Bordeaux.

Abstract

Brain cannabinoid CB1 receptors are centrally involved in the pathophysiology of psychoses. However, the mechanisms involved are scantly studied, because of the lack of suitable animal models.

Most of learning and memory studies in laboratory animals over the last decades focus on "direct" conditioning associations. In these settings, a conditioned stimulus with low-salience (i.e. with low intrinsic attractiveness or repulsiveness, such as a tone or a light) is temporally associated with an unconditioned high-salience stimulus (e.g. with high attractiveness or repulsiveness, such as shocks or food).

However, large part of learning processes involves "incidental" associations between low-salience stimuli, whose simultaneous occurrence is temporally stored because of its potential value for future experiences. Interestingly, alterations in different phases of incidental learning are thought to ground major psychopathological conditions, such as psychotic-like delusions.

Recent data from our laboratory show that hippocampal CB1 receptor signaling plays a key role in incidental learning processes in physiological and pathological conditions.

Guest of Stéphanie Fulton and Didier Jutras-Aswad. Cardiometabolic axis and Neurosciences axis.

This conference will be presented in English.

Friday, January 10, at noon
Auditorium of the CRCHUM , R05.210 and R05.220
900 Saint-Denis Street, 5th floor 
Montreal (Quebec), H2X 0A9

Giovanni Marsicano, Ph.D., D.M.V.
Research director INSERM, Team Endocannabinoids and Neuroadaptation, NeuroCentre Magendie, Université de Bordeaux

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